RAW DNA Imputation
This service imputes any RAW DNA data file (23andme, Ancestry, FTDNA, MyHeritage, LivingDNA, …) from 700K SNPs to 30 millions SNPs.
The imputation is performed using BEAGLE2, BCFTOOLS and 1000Genomes human reference panel. The result is a 23andme RAW format (around 250 Mbytes compressed ZIP file).
The imputation process only imputes the chromosomes 1-22. MTDNA and YDNA cannot be imputed.
The imputed file gets a free ancestry and traits report.
Please upload your file to the website and send us an email to email@example.com indicating which file you want to impute. The results will be available in the following 48 hours.
Once the results are ready, you will receive an email containing a link to the imputed file. You will find the ancestry & traits report in your account.
What are the differences between non-imputed and an imputed file ancestry & traits reports?
Your Recent ancestry might be similar if you already have a relatively homogeneous recent ancestry. This is, if all your known ancestors are from the same ethnic population group in the last 300 years, there would be just subtle differences. The Shared Origins report might show a further detailed ancient connection between your DNA and other world populations. You and those listed populations may share the same roots thousands of years, but it doesn't mean you have an ancestor from these populations.
Will the traits report improve after imputing my RAW DNA file?
Yes, your traits report also gets an improvement thanks to the extra SNPs. There you might find more traits that were inconclusive with your original RAW file.
Will the neanderthal report improve after imputing my RAW DNA file?
Yes, your neanderthal traits report also gets an improvement thanks to the extra SNPs. There you might find more traits that were inconclusive with your original RAW file.
Where can I upload the imputed RAW file?
This file can be uploaded to Gedmatch, Promethease and GenVue. As well, it can be used in Admixture Studio.
DISCLAIMER: Imputation service increases the number of SNPs using a statistical approach prone to miscall from 1% to 5% of the genotypes.. So, we recommend not to use it for health predictions. So, please, if you upload your imputed results to a website that offers health predictions, take into account there could be some false-positives or negatives.
More information about the DNA imputation: Ancestry.com article explaining DNA imputation.