What is the difference between single phasing and duo/trio phasing?

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What is the difference between single phasing and duo/trio phasing?

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Phasing services differ in accuracy and data requirements:

Single (Statistical) Phasing:

What it uses:

  • Only your DNA file
  • Statistical algorithms
  • Large reference populations
  • Population linkage patterns

How it works:

  • Analyzes patterns in your DNA
  • Compares to known haplotype blocks
  • Predicts most likely parental assignments
  • Uses probability models

Accuracy: 85-95%

Best for:

  • When parent DNA is unavailable
  • General ancestry analysis
  • Basic genealogy work
  • Budget-friendly option
Duo Phasing:

What it uses:

  • Your DNA file
  • ONE parent's DNA file
  • Direct comparison

How it works:

  • Directly compares your DNA to parent's DNA
  • Identifies which variants came from that parent
  • Infers remaining variants came from other parent
  • Minimal statistical guessing

Accuracy: 97-99%

Best for:

  • One parent available for testing
  • Deceased or unavailable parent
  • High-accuracy needs
Trio Phasing:

What it uses:

  • Your DNA file
  • Mother's DNA file
  • Father's DNA file
  • Complete direct comparison

How it works:

  • Direct comparison to both parents
  • Identifies exact inheritance from each
  • Nearly eliminates statistical uncertainty
  • Gold standard for phasing

Accuracy: 99%+

Best for:

  • Both parents available
  • Maximum accuracy needed
  • Research or medical purposes
  • Genealogy preservation
Comparison Table:
FeatureSingleDuoTrio
Files Needed1 (yours)2 (you + 1 parent)3 (you + both parents)
Accuracy85-95%97-99%99%+
CostLowestMediumHighest
Parent DNA RequiredNoOne parentBoth parents
Which Should You Choose?
  • Single: Parents unavailable, general use
  • Duo: One parent available, good balance
  • Trio: Both parents available, best results
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