Gluten tolerance

Food Sensitivities

Gluten tolerance here refers to research on how people without diagnosed celiac disease vary in how they respond to gluten-containing foods, sometimes described as non-celiac gluten sensitivity.

Most genetic signal in this area still comes from celiac-associated HLA variants, but additional variants tied to gut barrier and immune signaling have been studied.

This result reflects research-level variation and is not a diagnostic test for celiac disease, wheat allergy, or non-celiac gluten sensitivity.

Gut microbiome, FODMAP content, fiber intake, stress, infections, and other dietary components also shape how people feel after eating gluten.

All traits Compare samples

Selected sample: Demo Report
Report markers: 4 SNP entries
Genes: 0
Research: 1 study

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Average genetic tendency

Very Low Very High

Was this result accurate for you?

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Genotype	Variant allele	Frequency
rs2364484	CA		28.00%
rs17849502	--	T	6.00%
rs6806528	--	T	13.00%
rs9610686	--	T	39.00%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease

Evidence

Very strong scientific evidence

2020 Mar Eur J Hum Genet

Authors: Ricaño-Ponce I, Gutierrez-Achury J, Costa AF, Deelen P, Kurilshikov A, Zorro MM, Platteel M, van der Graaf A, , Sanna S, Daffra O, Zhernakova A, Fu J, Trynka G, Smecuol E, Niveloni SI, Bai JC, Kumar V, Wijmenga C

Study sample: 26,580 individuals (european ancestry)