Traits - Genetic tendency toward celiac disease
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Celiac disease is an autoimmune condition in which gluten triggers an immune response that damages the small intestine. It has one of the strongest known genetic components of any common autoimmune disease.
Most cases involve specific HLA-DQ variants (HLA-DQ2 and HLA-DQ8), with additional smaller-effect variants identified by GWAS.
This result reflects research-level variation linked to celiac susceptibility and is not a diagnostic test. Diagnosis requires medical evaluation, including blood antibodies and intestinal biopsy.
Gluten exposure, gut health, age of introduction, infections, and other environmental factors also influence whether susceptibility translates into actual disease.
Slightly higher tendency toward developing celiac disease. one copy of the HLA-DQ8 haplotype
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs7454108 | 6 | CT | 0.00% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
2005 Jan
Authors: Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, Hoffenberg EJ, Horvath K, Murray JA, Pivor M, Seidman EG,
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