Genetic associations studied in body-weight regulation

Obesity research uses body mass index (BMI) and related measures to study why some people accumulate more body fat than others. It is one of the most heritable common traits.

Hundreds of common variants have been linked to BMI, with FTO and MC4R among the strongest, often acting on appetite and energy balance rather than metabolism alone.

This result reflects research-level variation in body weight biology and is not a diagnosis or a weight-management plan.

Diet, physical activity, sleep, stress, medications, hormones, gut microbiome, and food environment have major effects on body weight regardless of genetic background.

3 SNPs

11 Studies

Sep 23, 2026

DEMO REPORT

Research Summary

What This Trait Studies

This section explains the population-level genetic research behind this trait. It is not an individual diagnosis or prediction.

Research summary, not an individual result

This trait is presented as population-level genetic research rather than an individual Low/High verdict, because the science behind it is either too preliminary, too easily misread as a diagnosis, or too sensitive to responsibly reduce to a single badge.

3 Genetic markers studied

3 Detected in your data

1 Gene analyzed

11 Research studies

Not an individual prediction. This section summarizes population-level genetic research. It is not a personal diagnosis, a screening result, or a claim about you specifically. If this topic is a health, behavioral, or wellbeing concern for you, please talk with a qualified professional rather than relying on this genetic report.

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Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

ADRB2 GeneCards

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

Genomic Location

Chr 5 Start: 148,826,611 End: 148,828,623 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs1042714	C C	G	C	79.57%	Detected
Your Genotype CC Reference Allele G Variant Allele C Population Frequency 79.57% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs1042714	5	CC	C	79.57%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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