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Genetic tendency toward peanut allergy

Food Sensitivities

Peanut allergy is an immune response to specific peanut proteins. It has a strong genetic component, especially in the HLA region and skin-barrier genes.

Variants in HLA-DR/DQ, FLG (filaggrin), and immune-regulatory genes have been linked to the chance of developing a peanut allergy.

This result reflects research-level variation in immune susceptibility and is not a diagnostic allergy test. Diagnosis requires clinical evaluation with skin tests, blood IgE, or supervised challenges.

Skin barrier health in infancy, early peanut exposure, eczema, family allergy history, and environment also strongly shape whether allergy actually develops.

All traits Compare samples

Selected sample: Demo Report
Report markers: 6 SNP entries
Genes: 1
Research: 2 studies

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Average tendency toward developing a peanut allergy

Very Low Very High

Was this result accurate for you?

Evidence and coverage

Confidence score

Very high

Read the evidence rating alongside the markers detected in your file. Confidence and tendency describe different aspects of this report.

Markers detected6 / 6100% coverage of report entries

Trait influence breakdown

Genetic 60% 60% Environment 40% 40%

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data

SNP: A specific genetic marker relevant to this trait.
Genotype: The DNA letters reported at a marker location.
Variant allele: The alternative DNA sequence at the SNP site.
Variant allele frequency: The reported percentage of the reference population carrying this variant.
Variant found: Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

HLA-DRA

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

GeneCards

Chromosome: 6
Start: 32,439,878
End: 32,445,046
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for HLA-DRA
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs7192	GG	T	G	65.95%	Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Chromosome	Genotype	Variant allele	Frequency
rs7192	6	GG	G	65.95%
rs9275596	6	TT	T	76.74%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Evidence

Very strong scientific evidence

2018 Mar J Allergy Clin Immunol

Authors: Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Ellis G, Ben-Shoshan M, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk RN, Dubois AEJ, Chin R, Cheuk S, Hoffman J, Jorgensen E, Witte JS, Melles RB, Hong X, Wang X, Hui J, Musk AWB, Hunter M, James AL, Koppelman GH, Sandford AJ, Clarke AE, Daley D

Study sample: 4,395 individuals (european ancestry)

IgE-Mediated Peanut Allergy: Current and Novel Predictive Biomarkers for Clinical Phenotypes Using Multi-Omics Approaches

Evidence

Statistical significance

01/28/2021

Authors: Czolk R, Klueber J, Sørensen M, Wilmes P, Codreanu-Morel F, Skov PS, Hilger C, Bindslev-Jensen C, Ollert M, Kuehn A