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Response to diet

Body Composition

This research area looks at how people vary in their physiological response to changes in diet (for example weight loss, lipid changes, or glucose control on the same eating plan).

GWAS work has examined variants linked to lipid metabolism, insulin sensitivity, and appetite regulation that may modify how the body responds to dietary changes.

This result reflects research-level variation in dietary response and is not a personalized diet plan.

Adherence, baseline body composition, activity, sleep, gut microbiome, medications, and overall health drive most of the real-world response to any diet.

All traits Compare samples

Selected sample: Demo Report
Report markers: 9 SNP entries
Genes: 3
Research: 3 studies

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Less weight gain on high fat diets

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Was this result accurate for you?

Evidence and coverage

Confidence score

Very high

Read the evidence rating alongside the markers detected in your file. Confidence and tendency describe different aspects of this report.

Markers detected9 / 9100% coverage of report entries

Trait influence breakdown

Genetic 60% 60% Environment 40% 40%

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data

SNP: A specific genetic marker relevant to this trait.
Genotype: The DNA letters reported at a marker location.
Variant allele: The alternative DNA sequence at the SNP site.
Variant allele frequency: The reported percentage of the reference population carrying this variant.
Variant found: Whether the variant was detected in your DNA file.

3 of 3 genes have detected genotypes.

ADIPOQ

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

GeneCards

Chromosome: 3
Start: 186,842,704
End: 186,858,463
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for ADIPOQ
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs17300539	AG	G	A	7.53%	Detected

APOA2

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

GeneCards

Chromosome: 1
Start: 161,222,292
End: 161,223,631
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for APOA2
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs5082	AG	G	A	76.30%	Detected

APOA5

The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

GeneCards

Chromosome: 11
Start: 116,789,367
End: 116,792,420
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for APOA5
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs662799	AG	G	A	83.71%	Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Chromosome	Genotype	Variant allele	Frequency
rs5082	1	AG	A	76.30%
rs17300539	3	AG	A	7.53%
rs662799	11	AG	A	83.71%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study

Evidence

Statistical significance

2007 Jun

Authors: Corella D, Arnett DK, Tsai MY, Kabagambe EK, Peacock JM, Hixson JE, Straka RJ, Province M, Lai CQ, Parnell LD, Borecki I, Ordovas JM

The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals

Evidence

Statistical significance

2008 Aug

Authors: Montagnana M, Fava C, Nilsson PM, Engström G, Hedblad B, Lippi G, Minuz P, Berglund G, Melander O

APOA-5 Genetic Variant rs662799: Role in Lipid Changes and Insulin Resistance after a Mediterranean Diet in Caucasian Obese Subjects

Evidence

Statistical significance

08/12/2021

Authors: de Luis D, Izaola O, Primo D

Genetic tendency

Behind this report

Genes analyzed

No genes match your search

SNPs tested

Research studies

The -256T&gt;C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study

The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals

APOA-5 Genetic Variant rs662799: Role in Lipid Changes and Insulin Resistance after a Mediterranean Diet in Caucasian Obese Subjects

The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study