Traits - Lead Levels
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Lead is a heavy metal with no useful role in the body. Researchers study blood lead levels because chronic exposure has measurable health effects.
Variants in genes that affect metal transport and detoxification (such as ALAD) have been linked to small differences in measured lead burden between people with similar exposure.
This result reflects research-level variation in how the body handles lead and is not a measurement of current exposure.
Environmental exposure (old paint, water pipes, contaminated soil, occupational settings) is by far the largest determinant of actual lead burden.
Average genetic tendency
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs1805313 | AG | 68.30% | ||
| rs8177812 | GA | A | 12.20% | |
| rs10121150 | -- | 78.60% | ||
| rs116864947 | -- | C | 98.30% | |
| rs12136530 | -- | 79.30% | ||
| rs144653651 | -- | A | 7.50% | |
| rs16968074 | -- | G | 68.60% | |
| rs2662776 | -- | G | 46.70% | |
| rs550057 | -- | 26.60% | ||
| rs60580184 | -- | A | 2.50% | |
| rs6462018 | -- | 50.40% | ||
| rs76153987 | -- | T | 5.00% | |
| rs79019069 | -- | G | 97.40% | |
| rs798338 | -- | A | 35.40% | |
| rs9863067 | -- | G | 90.40% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
Authors: Warrington NM, Zhu G, Dy V, Heath AC, Madden PA, Hemani G, Kemp JP, Mcmahon G, St Pourcain B, Timpson NJ, Taylor CM, Golding J, Lawlor DA, Steer C, Montgomery GW, Martin NG, Davey Smith G, Evans DM, Whitfield JB
Study sample: 5,433 individuals (nr ancestry)
