Traits - Vitamin B6 Levels

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Vitamin B6 Levels

Vitamin Metabolism

Vitamin B6 (pyridoxine and related forms) is a cofactor in many enzyme reactions, including amino acid and neurotransmitter metabolism.

GWAS work has identified variants in genes that handle B6 transport and metabolism, including ALPL, that contribute to differences in plasma B6.

This result reflects research-level variation in B6 handling and is not a serum B6 test or a supplement recommendation.

Diet, alcohol use, certain medications, kidney function, and pregnancy strongly affect real B6 status.

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Report markers
3 SNP entries
Genes
1
Research
2 studies
Your report

Genetic tendency

Average levels of vitamin B6

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Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data
SNP
A specific genetic marker relevant to this trait.
Genotype
The DNA letters reported at a marker location.
Variant allele
The alternative DNA sequence at the SNP site.
Variant allele frequency
The reported percentage of the reference population carrying this variant.
Variant found
Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

NBPF3

This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Feb 2013]

GeneCards
Chromosome
1
Start
21,436,775
End
21,485,005
Build
HG19
Associated SNPs 1 / 1 detected
Associated markers for NBPF3
SNPGenotype Ref. alleleVariant alleleFrequencyStatus
rs4654748 TT CT37.54%Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNPChromosomeGenotypeVariant alleleFrequency
rs46547481TTT37.54%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

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Coverage: 3/3 SNP entries detected (100%).

Reference: Human Genome Build 37 (HG19). Other testing companies may report using the opposite strand, requiring conversion for comparison.

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SAMPLE REPORT Example DNA profile This is a sample report with example data. It is not your personal report, and the results do not describe you.
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