Item-level analyses reveal genetic heterogeneity in neuroticism
Evidence Very strong scientific evidence
Authors: Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Study sample: 380,506 individuals (european ancestry)
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Genetic associations studied in mood-variability research
GeneralMood swings research studies inherited differences in how often and how strongly mood changes during everyday life.
GWAS work has identified variants linked to self-reported mood swings, with overlap with neuroticism and depression-related traits.
This result reflects research-level variation in mood-related traits and is not a clinical assessment.
Sleep, stress, hormones, life events, relationships, mental health, and overall well-being strongly shape mood swings in practice.
- Selected sample
- Demo Report
- Report markers
- 69 SNP entries
- Genes
- 0
- Research
- 1 study
Research summary
What this trait studies
Research summary, not an individual result
This trait is presented as population-level genetic research rather than an individual Low/High verdict, because the science behind it is either too preliminary, too easily misread as a diagnosis, or too sensitive to responsibly reduce to a single badge.
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Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs11712223 | CT | T | 39.09% | |
| rs6103271 | GG | G | 17.28% | |
| rs613872 | GT | T | 16.90% | |
| rs10188070 | GG | 34.94% | ||
| rs1563304 | CT | T | 17.25% | |
| rs28655666 | AA | A | 45.57% | |
| rs9671386 | GA | A | 25.62% | |
| rs11039149 | AG | G | 26.95% | |
| rs7202252 | CC | C | 26.66% | |
| rs11509880 | -- | A | 34.42% | |
| rs11687833 | -- | T | 39.41% | |
| rs11690710 | -- | 34.18% | ||
| rs11877496 | -- | T | 49.66% | |
| rs12137936 | -- | G | 30.71% | |
| rs12524535 | -- | G | 6.90% | |
| rs1261114 | -- | A | 38.03% | |
| rs1360379 | -- | T | 39.56% | |
| rs1440476 | -- | G | 39.33% | |
| rs17487484 | -- | 49.70% | ||
| rs1833070 | -- | A | 36.12% | |
| rs1890408 | -- | T | 12.11% | |
| rs1962104 | -- | 44.96% | ||
| rs2503775 | -- | G | 13.11% | |
| rs2678897 | -- | A | 38.86% | |
| rs34160346 | -- | 44.01% | ||
| rs34759087 | -- | T | 11.78% | |
| rs35789697 | -- | A | 35.82% | |
| rs35906288 | -- | 29.80% | ||
| rs4578918 | -- | 25.68% | ||
| rs4651205 | -- | T | 28.02% | |
| rs4836789 | -- | C | 40.29% | |
| rs56318386 | -- | T | 21.52% | |
| rs56403421 | -- | 32.70% | ||
| rs600011 | -- | C | 29.22% | |
| rs67447472 | -- | T | 10.42% | |
| rs68152875 | -- | A | 38.99% | |
| rs6889822 | -- | 38.57% | ||
| rs6895295 | -- | T | 22.37% | |
| rs784256 | -- | A | 18.50% | |
| rs7895261 | -- | G | 29.00% | |
| rs9344688 | -- | G | 35.18% | |
| rs9353806 | -- | A | 29.10% | |
| rs9852417 | -- | A | 40.15% | |
| rs10959813 | -- | A | 21.09% | |
| rs10983783 | -- | T | 44.67% | |
| rs11184994 | -- | T | 30.85% | |
| rs12896360 | -- | 32.01% | ||
| rs1373921 | -- | 23.03% | ||
| rs1427027 | -- | T | 26.90% | |
| rs17665188 | -- | 21.39% | ||
| rs1881193 | -- | 21.74% | ||
| rs199441 | -- | 21.75% | ||
| rs241036 | -- | C | 21.71% | |
| rs297346 | -- | 36.61% | ||
| rs55657917 | -- | G | 21.34% | |
| rs56059702 | -- | T | 44.33% | |
| rs5758268 | -- | 28.89% | ||
| rs79857651 | -- | A | 21.56% | |
| rs8002014 | -- | A | 25.53% | |
| rs9611567 | -- | G | 24.15% | |
| rs9929242 | -- | A | 47.12% | |
| rs11039409 | -- | C | 28.93% | |
| rs11082011 | -- | T | 34.40% | |
| rs11090039 | -- | A | 28.33% | |
| rs112333322 | -- | G | 21.50% | |
| rs12420205 | -- | T | 32.25% | |
| rs7104036 | -- | 38.66% | ||
| rs7107356 | -- | 49.50% | ||
| rs72995548 | -- | T | 6.22% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
Sample report with example data. Not your results.