Item-level analyses reveal genetic heterogeneity in neuroticism
Evidence Very strong scientific evidence
Authors: Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Study sample: 380,506 individuals (european ancestry)
Skip to results
Traits explorer / Individual report
Fed-up-feeling tendency
GeneralThis trait reflects a UK Biobank self-report item about how often someone feels fed-up, used as part of broader mood research.
GWAS work has identified variants linked to this self-report, with overlap with neuroticism and depression measures.
This result reflects research-level variation in mood-related traits and is not a clinical assessment.
Sleep, stress, life events, relationships, mental health support, and overall context strongly shape day-to-day mood.
- Selected sample
- Demo Report
- Report markers
- 60 SNP entries
- Genes
- 0
- Research
- 1 study
Your report
Genetic association
Choose whether to view this association. The evidence and its limitations remain available below.
Show my result for this trait
Average genetic tendency
Very Low
Very High
This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.
Was this result accurate for you?
Explore the evidence
Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs818215 | AC | C | 46.67% | |
| rs10838635 | AA | A | 24.72% | |
| rs4625 | AG | G | 30.33% | |
| rs7482876 | -- | 33.03% | ||
| rs77087420 | -- | G | 5.24% | |
| rs783537 | -- | G | 35.14% | |
| rs784256 | -- | A | 18.50% | |
| rs7912226 | -- | A | 40.09% | |
| rs9842349 | -- | T | 30.71% | |
| rs9852529 | -- | A | 28.87% | |
| rs9867227 | -- | 28.26% | ||
| rs9946342 | -- | A | 29.52% | |
| rs997091 | -- | 36.74% | ||
| rs10044479 | -- | C | 43.62% | |
| rs10144845 | -- | T | 32.03% | |
| rs10409264 | -- | A | 17.19% | |
| rs10794221 | -- | 35.49% | ||
| rs34668726 | -- | 16.47% | ||
| rs10902324 | -- | T | 30.41% | |
| rs11209175 | -- | T | 37.25% | |
| rs11532157 | -- | T | 30.13% | |
| rs12284535 | -- | 29.30% | ||
| rs12417519 | -- | T | 23.30% | |
| rs1275411 | -- | C | 34.12% | |
| rs1400868 | -- | 12.28% | ||
| rs143668283 | -- | A | 0.59% | |
| rs1439253 | -- | A | 42.19% | |
| rs17018482 | -- | A | 19.17% | |
| rs17194468 | -- | T | 11.50% | |
| rs1875560 | -- | 42.28% | ||
| rs199443 | -- | T | 20.68% | |
| rs2149351 | -- | G | 23.90% | |
| rs2262536 | -- | 29.16% | ||
| rs2696497 | -- | T | 21.38% | |
| rs34641928 | -- | G | 23.27% | |
| rs3758666 | -- | 24.81% | ||
| rs4309155 | -- | 33.62% | ||
| rs4391797 | -- | T | 30.61% | |
| rs4421114 | -- | T | 44.14% | |
| rs4630591 | -- | T | 19.88% | |
| rs4632195 | -- | T | 49.55% | |
| rs4799949 | -- | T | 34.46% | |
| rs4856268 | -- | 37.75% | ||
| rs4899292 | -- | 34.04% | ||
| rs55854228 | -- | A | 5.23% | |
| rs55965054 | -- | T | 45.30% | |
| rs56006260 | -- | G | 25.60% | |
| rs56214516 | -- | C | 18.92% | |
| rs599550 | -- | A | 14.78% | |
| rs6031966 | -- | T | 46.80% | |
| rs6130328 | -- | A | 38.31% | |
| rs61744010 | -- | T | 43.79% | |
| rs61978932 | -- | T | 31.34% | |
| rs62055544 | -- | G | 21.66% | |
| rs6718635 | -- | C | 12.97% | |
| rs6862766 | -- | T | 44.65% | |
| rs692360 | -- | 35.23% | ||
| rs72793213 | -- | 26.88% | ||
| rs72796402 | -- | G | 13.22% | |
| rs7334060 | -- | C | 35.74% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
Sample report with example data. Not your results.