Item-level analyses reveal genetic heterogeneity in neuroticism
Evidence Very strong scientific evidence
Authors: Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Study sample: 380,506 individuals (european ancestry)
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Traits explorer / Individual report
Guilt-feeling tendency
GeneralThis trait reflects a UK Biobank self-report item about how often someone feels guilty, used in broader mood and personality research.
GWAS work has identified variants linked to this self-report, with overlap with neuroticism and depression measures.
This result reflects research-level variation in mood-related traits and is not a clinical assessment.
Cultural background, upbringing, life events, mental health, and current context strongly shape feelings of guilt.
- Selected sample
- Demo Report
- Report markers
- 29 SNP entries
- Genes
- 0
- Research
- 1 study
Your report
Genetic association
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Average genetic tendency
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This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.
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Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs10119773 | AG | G | 46.60% | |
| rs10789942 | GG | G | 47.69% | |
| rs12420205 | -- | T | 32.25% | |
| rs12528131 | -- | 48.26% | ||
| rs12616250 | -- | C | 14.89% | |
| rs149949 | -- | C | 14.63% | |
| rs1557339 | -- | A | 26.19% | |
| rs1736904 | -- | A | 21.60% | |
| rs199525 | -- | 20.72% | ||
| rs200988 | -- | 28.24% | ||
| rs2109648 | -- | A | 36.04% | |
| rs2696532 | -- | G | 21.22% | |
| rs34657012 | -- | A | 27.90% | |
| rs34961555 | -- | T | 9.73% | |
| rs35623509 | -- | 27.15% | ||
| rs4471723 | -- | T | 21.93% | |
| rs524440 | -- | 4.48% | ||
| rs55769038 | -- | A | 42.20% | |
| rs56343114 | -- | 14.37% | ||
| rs62062288 | -- | A | 21.15% | |
| rs681875 | -- | A | 20.63% | |
| rs6910838 | -- | 38.84% | ||
| rs6986 | -- | C | 22.33% | |
| rs7569424 | -- | G | 14.48% | |
| rs77804065 | -- | T | 21.72% | |
| rs780024 | -- | A | 34.14% | |
| rs9366697 | -- | 36.64% | ||
| rs9461218 | -- | A | 24.79% | |
| rs9467707 | -- | C | 12.85% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
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