Item-level analyses reveal genetic heterogeneity in neuroticism
Evidence Very strong scientific evidence
Authors: Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Study sample: 380,506 individuals (european ancestry)
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Traits explorer / Individual report
Low-mood tendency
GeneralThis trait reflects a UK Biobank self-report item about how often someone feels miserable, used in broader mood research.
GWAS work has identified variants linked to this self-report, with overlap with neuroticism and depression.
This result reflects research-level variation in mood-related traits and is not a clinical assessment.
Sleep, stress, life events, mental health support, and current context strongly shape day-to-day mood.
- Selected sample
- Demo Report
- Report markers
- 64 SNP entries
- Genes
- 0
- Research
- 1 study
Your report
Genetic association
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Average genetic tendency
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This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.
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Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs10769256 | TT | T | 40.24% | |
| rs11039149 | AG | G | 26.95% | |
| rs11599236 | TC | 40.74% | ||
| rs17681615 | GA | A | 32.93% | |
| rs1994247 | GT | T | 47.95% | |
| rs2312147 | TC | 37.60% | ||
| rs3936093 | AG | 43.29% | ||
| rs836927 | AA | A | 43.63% | |
| rs9586 | TT | T | 22.00% | |
| rs10156548 | -- | C | 37.05% | |
| rs113829044 | -- | C | 3.51% | |
| rs114224598 | -- | A | 4.56% | |
| rs114306779 | -- | T | 4.55% | |
| rs11608355 | -- | C | 31.68% | |
| rs11659803 | -- | A | 38.31% | |
| rs12359689 | -- | A | 10.84% | |
| rs12945855 | -- | C | 46.79% | |
| rs13018407 | -- | 34.25% | ||
| rs1378358 | -- | T | 20.63% | |
| rs140581634 | -- | T | 3.07% | |
| rs140588606 | -- | A | 2.97% | |
| rs1422191 | -- | A | 16.59% | |
| rs146918648 | -- | A | 4.21% | |
| rs17192757 | -- | A | 13.26% | |
| rs17309825 | -- | C | 3.92% | |
| rs17501820 | -- | T | 40.47% | |
| rs17577369 | -- | 21.57% | ||
| rs17805214 | -- | T | 15.45% | |
| rs1971655 | -- | T | 49.21% | |
| rs2042555 | -- | A | 41.05% | |
| rs2732708 | -- | T | 21.40% | |
| rs35609938 | -- | 49.48% | ||
| rs35994060 | -- | 38.79% | ||
| rs3795310 | -- | T | 45.94% | |
| rs41286287 | -- | A | 7.07% | |
| rs41304550 | -- | T | 2.26% | |
| rs4245154 | -- | G | 43.11% | |
| rs4424705 | -- | A | 25.67% | |
| rs45510091 | -- | G | 5.23% | |
| rs4752801 | -- | G | 36.10% | |
| rs4757142 | -- | A | 40.34% | |
| rs55731231 | -- | G | 22.12% | |
| rs55854228 | -- | A | 5.23% | |
| rs55893771 | -- | T | 14.55% | |
| rs56280951 | -- | A | 21.43% | |
| rs59187049 | -- | C | 30.41% | |
| rs628246 | -- | 17.18% | ||
| rs67932684 | -- | G | 39.03% | |
| rs7107356 | -- | 49.50% | ||
| rs7128325 | -- | A | 32.71% | |
| rs72781632 | -- | C | 13.27% | |
| rs72786276 | -- | A | 12.96% | |
| rs72825713 | -- | T | 11.02% | |
| rs75035127 | -- | G | 2.97% | |
| rs7534703 | -- | T | 2.06% | |
| rs75650221 | -- | T | 3.86% | |
| rs7613360 | -- | T | 38.65% | |
| rs76785379 | -- | T | 2.24% | |
| rs77154778 | -- | A | 2.20% | |
| rs77417259 | -- | A | 2.96% | |
| rs7912226 | -- | A | 40.09% | |
| rs8097041 | -- | T | 37.54% | |
| rs848286 | -- | 36.90% | ||
| rs868150 | -- | 41.08% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
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