Item-level analyses reveal genetic heterogeneity in neuroticism
Evidence Very strong scientific evidence
Authors: Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Study sample: 380,506 individuals (european ancestry)
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Irritability tendency
GeneralIrritable mood research uses self-report items to study how easily people feel irritated or annoyed.
GWAS work has identified variants linked to self-reported irritability, with overlap with neuroticism and other mood-related traits.
This result reflects research-level variation in mood-related traits and is not a clinical assessment.
Sleep, stress, hunger, life events, mental health, and overall context strongly shape day-to-day irritability.
- Selected sample
- Demo Report
- Report markers
- 67 SNP entries
- Genes
- 0
- Research
- 1 study
Your report
Genetic association
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Average genetic tendency
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This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.
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Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs11682175 | TC | C | 46.61% | |
| rs1542212 | GG | 39.31% | ||
| rs1916977 | TT | T | 29.91% | |
| rs2217127 | GG | 29.06% | ||
| rs3026401 | CT | T | 21.84% | |
| rs3772556 | CT | T | 28.79% | |
| rs4634342 | GT | T | 36.18% | |
| rs631140 | GG | G | 27.57% | |
| rs6969188 | GA | A | 43.86% | |
| rs9527336 | AA | A | 27.72% | |
| rs9938550 | AG | 38.47% | ||
| rs1422192 | -- | A | 16.56% | |
| rs6596771 | -- | A | 48.67% | |
| rs12886000 | -- | T | 10.55% | |
| rs13223152 | -- | 40.17% | ||
| rs16884419 | -- | A | 24.35% | |
| rs17151565 | -- | 38.93% | ||
| rs17592462 | -- | T | 18.89% | |
| rs17650842 | -- | G | 21.66% | |
| rs17661015 | -- | C | 21.51% | |
| rs1927903 | -- | C | 34.19% | |
| rs2106785 | -- | T | 21.38% | |
| rs2261201 | -- | 21.46% | ||
| rs2587410 | -- | T | 25.31% | |
| rs2717033 | -- | 38.92% | ||
| rs28758902 | -- | T | 43.25% | |
| rs3110417 | -- | G | 25.15% | |
| rs3124405 | -- | T | 27.71% | |
| rs343949 | -- | 17.20% | ||
| rs35255819 | -- | A | 12.64% | |
| rs3774800 | -- | A | 35.40% | |
| rs4411173 | -- | A | 16.25% | |
| rs4499638 | -- | 37.04% | ||
| rs4570961 | -- | T | 32.42% | |
| rs4734804 | -- | G | 22.03% | |
| rs4781534 | -- | C | 34.36% | |
| rs4820434 | -- | T | 31.44% | |
| rs4953152 | -- | A | 31.51% | |
| rs507078 | -- | T | 29.60% | |
| rs58446129 | -- | T | 15.60% | |
| rs62055701 | -- | A | 21.45% | |
| rs62065453 | -- | T | 21.72% | |
| rs62211616 | -- | A | 17.92% | |
| rs62212173 | -- | T | 13.81% | |
| rs6549048 | -- | A | 29.25% | |
| rs6711058 | -- | A | 26.63% | |
| rs6718682 | -- | T | 27.49% | |
| rs6800177 | -- | T | 25.90% | |
| rs6861691 | -- | C | 43.30% | |
| rs70600 | -- | T | 20.72% | |
| rs7231748 | -- | G | 30.70% | |
| rs7265992 | -- | A | 18.09% | |
| rs7535528 | -- | A | 36.26% | |
| rs776472 | -- | T | 43.89% | |
| rs7973253 | -- | G | 36.97% | |
| rs9403716 | -- | A | 22.71% | |
| rs9630740 | -- | 26.17% | ||
| rs999483 | -- | 24.79% | ||
| rs10071595 | -- | A | 48.61% | |
| rs102275 | -- | 35.60% | ||
| rs10228350 | -- | 41.29% | ||
| rs10905619 | -- | 25.49% | ||
| rs10905638 | -- | C | 44.09% | |
| rs11067376 | -- | G | 35.95% | |
| rs2959025 | -- | 34.89% | ||
| rs1158960 | -- | 24.87% | ||
| rs6087607 | -- | 17.67% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
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