Traits - Worry tendency
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Worry research uses self-report scales to measure how often and how strongly people worry in everyday life.
GWAS work has identified variants linked to self-reported worry, with overlap with anxiety and neuroticism traits.
This result reflects research-level variation in mood-related traits and is not a clinical assessment of anxiety.
Sleep, stress, life events, mental health support, and current context strongly shape day-to-day worry.
Choose whether to view this association. The evidence and its limitations remain available below.
Higher worry tendency
This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs10005233 | TT | 33.19% | ||
| rs1572982 | AA | A | 59.07% | |
| rs1593304 | GG | 40.58% | ||
| rs17196295 | AG | G | 10.40% | |
| rs353547 | CC | 34.68% | ||
| rs1938386 | GT | T | 56.93% | |
| rs9671386 | GA | 26.68% | ||
| rs9811546 | GA | A | 22.78% | |
| rs1163085 | GA | A | 63.90% | |
| rs1248860 | GA | 44.73% | ||
| rs12938031 | GG | G | 17.07% | |
| rs2710323 | CC | C | 52.18% | |
| rs3026401 | CT | 35.68% | ||
| rs7152906 | TC | 65.81% | ||
| rs722599 | CC | C | 41.43% | |
| rs7355953 | TC | C | 10.00% | |
| rs888415 | GG | 45.77% | ||
| rs1017730 | GA | A | 16.99% | |
| rs10769256 | TT | T | 35.96% | |
| rs10871777 | AG | G | 24.58% | |
| rs1539844 | GA | A | 8.65% | |
| rs9829032 | AG | G | 38.10% | |
| rs9966951 | GA | A | 32.71% | |
| rs3740688 | TT | 36.08% | ||
| rs3897644 | CT | 49.22% | ||
| rs9870384 | CT | T | 22.98% | |
| rs10034259 | -- | C | 14.32% | |
| rs13324323 | -- | T | 22.78% | |
| rs150491901 | -- | A | 4.87% | |
| rs28639817 | -- | G | 15.24% | |
| rs332828 | -- | A | 35.46% | |
| rs34644694 | -- | 29.91% | ||
| rs391236 | -- | G | 19.29% | |
| rs4405857 | -- | 39.36% | ||
| rs4684833 | -- | 20.31% | ||
| rs480330 | -- | T | 41.95% | |
| rs483143 | -- | C | 12.60% | |
| rs488359 | -- | G | 57.65% | |
| rs502652 | -- | T | 19.73% | |
| rs57360718 | -- | C | 8.03% | |
| rs61731122 | -- | A | 0.90% | |
| rs62253085 | -- | 45.43% | ||
| rs62551581 | -- | C | 8.89% | |
| rs7033345 | -- | C | 38.66% | |
| rs7567451 | -- | T | 56.67% | |
| rs78260322 | -- | G | 3.17% | |
| rs79827531 | -- | A | 12.16% | |
| rs998884 | -- | G | 38.98% | |
| rs12188167 | -- | G | 6.77% | |
| rs2488401 | -- | T | 23.64% | |
| rs2672852 | -- | 45.61% | ||
| rs1724725 | -- | 2.04% | ||
| rs17532098 | -- | T | 5.03% | |
| rs2236939 | -- | T | 11.16% | |
| rs13262595 | -- | 24.04% | ||
| rs2413631 | -- | A | 19.17% | |
| rs2435210 | -- | T | 25.14% | |
| rs246914 | -- | C | 12.46% | |
| rs11663050 | -- | G | 45.67% | |
| rs12145083 | -- | A | 16.21% | |
| rs12260436 | -- | C | 35.54% | |
| rs12484971 | -- | T | 25.16% | |
| rs12765002 | -- | T | 28.17% | |
| rs12923795 | -- | 69.27% | ||
| rs12957516 | -- | 53.25% | ||
| rs13094915 | -- | C | 55.05% | |
| rs13282237 | -- | G | 60.22% | |
| rs1330745 | -- | C | 11.00% | |
| rs13328187 | -- | C | 14.48% | |
| rs1368748 | -- | 50.40% | ||
| rs28426374 | -- | T | 52.38% | |
| rs3117425 | -- | T | 4.45% | |
| rs3124377 | -- | 40.12% | ||
| rs3742020 | -- | C | 33.65% | |
| rs3751855 | -- | C | 47.96% | |
| rs3988211 | -- | 2.82% | ||
| rs4245150 | -- | 19.61% | ||
| rs4752856 | -- | A | 25.72% | |
| rs4799723 | -- | 21.59% | ||
| rs4856278 | -- | 16.75% | ||
| rs4937872 | -- | G | 60.94% | |
| rs525773 | -- | A | 56.09% | |
| rs55997507 | -- | 42.53% | ||
| rs56084168 | -- | T | 16.49% | |
| rs56133711 | -- | A | 11.34% | |
| rs589092 | -- | 52.10% | ||
| rs59735493 | -- | A | 43.55% | |
| rs60642411 | -- | A | 24.94% | |
| rs61734645 | -- | G | 1.96% | |
| rs61991614 | -- | A | 14.24% | |
| rs62064641 | -- | C | 8.69% | |
| rs62081501 | -- | A | 5.41% | |
| rs62081537 | -- | C | 17.01% | |
| rs62096058 | -- | A | 33.57% | |
| rs62250661 | -- | A | 40.83% | |
| rs6445541 | -- | T | 33.75% | |
| rs6478623 | -- | G | 36.14% | |
| rs6807666 | -- | 35.48% | ||
| rs6851494 | -- | 31.35% | ||
| rs7023933 | -- | T | 28.85% | |
| rs7207400 | -- | C | 26.30% | |
| rs7220839 | -- | T | 41.05% | |
| rs72893199 | -- | C | 15.81% | |
| rs730356 | -- | A | 12.20% | |
| rs75195552 | -- | A | 9.01% | |
| rs75614054 | -- | T | 5.15% | |
| rs76508707 | -- | T | 45.33% | |
| rs77420391 | -- | A | 15.16% | |
| rs77432625 | -- | G | 5.39% | |
| rs80533 | -- | 17.41% | ||
| rs8067056 | -- | C | 30.91% | |
| rs818219 | -- | C | 58.71% | |
| rs9936170 | -- | G | 45.55% | |
| rs9861237 | -- | C | 34.86% | |
| rs9836178 | -- | 27.30% | ||
| rs10501320 | -- | C | 8.83% | |
| rs10507274 | -- | C | 2.42% | |
| rs10850379 | -- | T | 34.11% | |
| rs11090045 | -- | A | 21.29% | |
| rs11159097 | -- | C | 31.67% | |
| rs11191392 | -- | A | 51.46% | |
| rs11204421 | -- | C | 38.76% | |
| rs112591851 | -- | T | 0.90% | |
| rs1426371 | -- | A | 25.66% | |
| rs1427041 | -- | 25.06% | ||
| rs16902946 | -- | C | 0.00% | |
| rs1826787 | -- | T | 22.98% | |
| rs1890184 | -- | C | 42.31% | |
| rs9854869 | -- | A | 11.22% | |
| rs3213716 | -- | A | 31.15% | |
| rs34011394 | -- | T | 28.85% | |
| rs34135146 | -- | C | 4.53% | |
| rs34569203 | -- | C | 9.66% | |
| rs352140 | -- | 58.45% | ||
| rs3740393 | -- | C | 21.03% | |
| rs3740397 | -- | C | 35.02% | |
| rs3785879 | -- | A | 46.77% | |
| rs4434138 | -- | G | 34.13% | |
| rs4526367 | -- | 21.81% | ||
| rs4687552 | -- | C | 30.97% | |
| rs2194027 | -- | A | 31.89% | |
| rs1998122 | -- | A | 31.09% | |
| rs9896243 | -- | G | 12.32% | |
| rs1296171 | -- | G | 55.85% | |
| rs2407746 | -- | G | 22.56% | |
| rs9837462 | -- | A | 15.81% | |
| rs9828595 | -- | G | 23.04% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
Authors: Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, , White T, Tiemeier H, Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D
Study sample: 688,809 individuals (european ancestry)
