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Eruption of permanent teeth

Physical Traits

The timing of permanent tooth eruption in childhood varies between people and is partly heritable.

GWAS work has identified variants near tooth-development genes (such as KCNJ2 and EDA) linked to differences in eruption timing.

This result reflects research-level variation in dental biology and is not a clinical assessment of dental development.

Nutrition, growth, oral health, primary tooth loss timing, and overall development also affect when permanent teeth come in.

All traits Compare samples

Selected sample: Demo Report
Report markers: 6 SNP entries
Genes: 2
Research: 2 studies

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Less number of permanent teeth before 14 years old

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Evidence and coverage

Confidence score

Very high

Read the evidence rating alongside the markers detected in your file. Confidence and tendency describe different aspects of this report.

Markers detected6 / 6100% coverage of report entries

Trait influence breakdown

Genetic 85% 85% Environment 15% 15%

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data

SNP: A specific genetic marker relevant to this trait.
Genotype: The DNA letters reported at a marker location.
Variant allele: The alternative DNA sequence at the SNP site.
Variant allele frequency: The reported percentage of the reference population carrying this variant.
Variant found: Whether the variant was detected in your DNA file.

2 of 2 genes have detected genotypes.

ADK

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards

Chromosome: 10
Start: 74,151,185
End: 74,709,963
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for ADK
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs7924176	GG	A	G	18.11%	Detected

CACNA1S

This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]

GeneCards

Chromosome: 1
Start: 201,039,509
End: 201,112,453
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for CACNA1S
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs2281845	CT	C	T	58.89%	Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Chromosome	Genotype	Variant allele	Frequency
rs2281845	1	CT	T	58.89%
rs7924176	10	GG	G	18.11%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Evidence

Very strong scientific evidence

02/26/2010 PLoS Genet

Authors: Pillas D, Hoggart CJ, Evans DM, O&#39, Reilly PF, Sipilä K, Lähdesmäki R, Millwood IY, Kaakinen M, Netuveli G, Blane D, Charoen P, Sovio U, Pouta A, Freimer N, Hartikainen AL, Laitinen J, Vaara S, Glaser B, Crawford P, Timpson NJ, Ring SM, Deng G, Zhang W, McCarthy MI, Deloukas P, Peltonen L, Elliott P, Coin LJ, Smith GD, Jarvelin MR

Study sample: 5,752 individuals (european ancestry)

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances

Evidence

Very strong scientific evidence

09/15/2013 Hum Mol Genet

Authors: Fatemifar G, Hoggart CJ, Paternoster L, Kemp JP, Prokopenko I, Horikoshi M, Wright VJ, Tobias JH, Richmond S, Zhurov AI, Toma AM, Pouta A, Taanila A, Sipila K, Lähdesmäki R, Pillas D, Geller F, Feenstra B, Melbye M, Nohr EA, Ring SM, St Pourcain B, Timpson NJ, Davey Smith G, Jarvelin MR, Evans DM

Study sample: 11,513 individuals (european ancestry)