Traits - Hair curl pattern

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Hair curl pattern

Hair & Skin

Hair curl pattern depends on the shape and size of the hair follicle and on cross-links inside the hair shaft.

Variants in TCHH (trichohyalin), EDAR, and other hair structure genes have been linked to differences in hair curl across populations.

This result reflects research-level variation in hair biology and is not direct observation of curl pattern.

Humidity, hair length, hair care products, age, and damage all strongly affect how hair curl looks day to day.

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Report markers
3 SNP entries
Genes
1
Research
5 studies
Your report

Genetic tendency

Less likely to have straighter hair

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Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data
SNP
A specific genetic marker relevant to this trait.
Genotype
The DNA letters reported at a marker location.
Variant allele
The alternative DNA sequence at the SNP site.
Variant allele frequency
The reported percentage of the reference population carrying this variant.
Variant found
Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

TCHHL1

This gene belongs to the S100 fused-type protein (SFTP) gene family, and is located in a cluster of SFTP genes on chromosome 1q21. Several members of this family have been implicated in the development of complex skin disorders. This gene is evolutionarily conserved; its expression appears to be hair-specific and spatially restricted within the distal inner root sheath of the hair follicle. It thus may have an important role in hair morphogenesis. [provided by RefSeq, Aug 2013]

GeneCards
Chromosome
1
Start
152,084,141
End
152,089,064
Build
HG19
Associated SNPs 1 / 1 detected
Associated markers for TCHHL1
SNPGenotype Ref. alleleVariant alleleFrequencyStatus
rs17646946 AG GA11.32%Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNPChromosomeGenotypeVariant alleleFrequency
rs176469461AGA11.32%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair

EvidenceVery strong scientific evidence

02/01/2018 Hum Mol Genet

Authors: Liu F, Chen Y, Zhu G, Hysi PG, Wu S, Adhikari K, Breslin K, Pospiech E, Hamer MA, Peng F, Muralidharan C, Acuna-Alonzo V, Canizales-Quinteros S, Bedoya G, Gallo C, Poletti G, Rothhammer F, Bortolini MC, Gonzalez-Jose R, Zeng C, Xu S, Jin L, Uitterlinden AG, Ikram MA, van Duijn CM, Nijsten T, Walsh S, Branicki W, Wang S, Ruiz-Linares A, Spector TD, Martin NG, Medland SE, Kayser M

Study sample: 16,763 individuals (european ancestry)

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Coverage: 3/3 SNP entries detected (100%).

Reference: Human Genome Build 37 (HG19). Other testing companies may report using the opposite strand, requiring conversion for comparison.

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