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Iris crypts

Facial Features

Iris crypts are small openings in the front layer of the iris, contributing to overall iris pattern.

GWAS work on iris features has identified variants near genes involved in iris development and pigmentation linked to crypts.

This result reflects research-level variation in iris biology and is not direct observation of any individual's iris.

Iris features can also change subtly with age, and pigment changes can affect how crypts appear.

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Selected sample: Demo Report
Report markers: 3 SNP entries
Genes: 1
Research: 1 study

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Only parallel and/or densely packed curly fibers

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Evidence and coverage

Confidence score

Very high

Read the evidence rating alongside the markers detected in your file. Confidence and tendency describe different aspects of this report.

Markers detected3 / 3100% coverage of report entries

Trait influence breakdown

Genetic 85% 85% Environment 15% 15%

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data

SNP: A specific genetic marker relevant to this trait.
Genotype: The DNA letters reported at a marker location.
Variant allele: The alternative DNA sequence at the SNP site.
Variant allele frequency: The reported percentage of the reference population carrying this variant.
Variant found: Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

SEMA3A

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards

Chromosome: 7
Start: 83,955,777
End: 84,515,189
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for SEMA3A
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs10235789	CC	T	C	28.12%	Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Chromosome	Genotype	Variant allele	Frequency
rs10235789	7	CC	C	28.12%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development

Evidence

Very strong scientific evidence

08/12/2011 Am J Hum Genet

Authors: Larsson M, Duffy DL, Zhu G, Liu JZ, Macgregor S, McRae AF, Wright MJ, Sturm RA, Mackey DA, Montgomery GW, Martin NG, Medland SE

Study sample: 2,121 individuals (european ancestry)