Traits - Astigmatism susceptibility
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Corneal astigmatism is a refractive error caused by an irregular curvature of the cornea, leading to blurred vision at multiple distances.
GWAS work has identified variants linked to corneal shape and astigmatism susceptibility.
This result reflects research-level variation in eye biology and is not an eye exam or a vision prescription.
Eye growth, age, and other refractive conditions also influence actual astigmatism.
Lower astigmatism susceptibility tendency
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs1623169 | TT | T | 92.99% | |
| rs830557 | CT | 52.90% | ||
| rs11238956 | TC | C | 17.13% | |
| rs1129038 | TT | 21.50% | ||
| rs12913832 | GG | 82.27% | ||
| rs1353386 | AC | 14.80% | ||
| rs11084579 | -- | A | 66.60% | |
| rs62075722 | -- | G | 84.48% | |
| rs142566675 | -- | A | 0.16% | |
| rs149846728 | -- | A | 94.90% | |
| rs1579050 | -- | G | 42.50% | |
| rs16971637 | -- | C | 95.90% | |
| rs196052 | -- | 62.20% | ||
| rs2445565 | -- | 47.00% | ||
| rs9517490 | -- | C | 30.00% | |
| rs10223780 | -- | G | 51.76% | |
| rs10279904 | -- | T | 98.70% | |
| rs10993820 | -- | G | 79.10% | |
| rs112947941 | -- | G | 93.10% | |
| rs115822495 | -- | T | 0.34% | |
| rs11639295 | -- | T | 37.86% | |
| rs117023057 | -- | 98.40% | ||
| rs11955682 | -- | T | 2.78% | |
| rs12032649 | -- | G | 61.40% | |
| rs12473604 | -- | 77.50% | ||
| rs12551905 | -- | C | 98.50% | |
| rs138016380 | -- | 97.60% | ||
| rs2763272 | -- | T | 11.50% | |
| rs35313216 | -- | 92.80% | ||
| rs4864857 | -- | C | 78.40% | |
| rs56274409 | -- | T | 94.40% | |
| rs61935843 | -- | 91.80% | ||
| rs62169220 | -- | G | 85.00% | |
| rs6434068 | -- | C | 28.23% | |
| rs6536686 | -- | 19.20% | ||
| rs6741982 | -- | G | 96.10% | |
| rs72629670 | -- | G | 37.72% | |
| rs75380963 | -- | T | 2.34% | |
| rs7931326 | -- | G | 93.50% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
Authors: Shah RL, Guggenheim JA,
Study sample: 86,335 individuals (european ancestry)
