Psoriasis susceptibility

Skin Health

Psoriasis is a chronic immune-mediated skin condition that causes scaly, inflamed plaques.

GWAS work has identified more than 60 variants linked to psoriasis, including strong signals in the HLA region (HLA-C*06:02) and in IL-23 signaling.

This result reflects research-level variation in immune biology and is not a clinical diagnosis of psoriasis.

Triggers (skin trauma, infections, stress, smoking, certain medications) and other autoimmune conditions also affect actual psoriasis course.

All traits Compare samples

Selected sample: Demo Report
Report markers: 6 SNP entries
Genes: 0
Research: 1 study

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Average genetic tendency

Very Low Very High

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Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Genotype	Variant allele	Frequency
rs4685408	GA		48.00%
rs7637230	--		80.00%
rs35343117	--	G	34.00%
rs10789285	--	G	25.00%
rs114934997	--		91.00%
rs2675662	--		56.00%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Evidence

Very strong scientific evidence

05/05/2015 Nat Commun

Authors: Tsoi LC, Spain SL, Ellinghaus E, Stuart PE, Capon F, Knight J, Tejasvi T, Kang HM, Allen MH, Lambert S, Stoll SW, Weidinger S, Gudjonsson JE, Koks S, Kingo K, Esko T, Das S, Metspalu A, Weichenthal M, Enerback C, Krueger GG, Voorhees JJ, Chandran V, Rosen CF, Rahman P, Gladman DD, Reis A, Nair RP, Franke A, Barker JNWN, Abecasis GR, Trembath RC, Elder JT

Study sample: 10,740 individuals (nr ancestry)