Traits - Rosacea susceptibility
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Rosacea is a chronic skin condition that causes facial redness, flushing, and sometimes bumps or visible blood vessels.
GWAS work has identified variants near HLA, IL-13, and other immune-related genes linked to rosacea susceptibility and symptom severity.
This result reflects research-level variation in skin biology and is not a clinical diagnosis.
Triggers (sun, heat, alcohol, spicy food, stress) and skin care strongly affect actual rosacea symptoms.
Average genetic tendency
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs13223215 | CC | 9.23% | ||
| rs719802 | CC | 50.66% | ||
| rs77779142 | CT | T | 10.60% | |
| rs788731 | GA | 44.19% | ||
| rs1129038 | TT | T | 17.69% | |
| rs6598858 | CT | T | 38.86% | |
| rs847 | CC | 24.70% | ||
| rs11768410 | -- | T | 47.30% | |
| rs118006792 | -- | C | 0.08% | |
| rs12243257 | -- | A | 6.37% | |
| rs138330605 | -- | G | 0.12% | |
| rs142431388 | -- | G | 0.04% | |
| rs143178873 | -- | 17.21% | ||
| rs144882124 | -- | G | 0.12% | |
| rs147606948 | -- | C | 0.36% | |
| rs147863159 | -- | T | 0.12% | |
| rs180789526 | -- | 99.98% | ||
| rs183739760 | -- | 99.98% | ||
| rs34278912 | -- | A | 12.98% | |
| rs7075455 | -- | G | 45.89% | |
| rs7130337 | -- | G | 51.70% | |
| rs73705028 | -- | C | 5.73% | |
| rs74500669 | -- | A | 0.92% | |
| rs77184728 | -- | A | 0.14% | |
| rs78911933 | -- | A | 6.65% | |
| rs80105877 | -- | 94.03% | ||
| rs1805007 | -- | T | 1.86% | |
| rs146167956 | -- | T | 0.20% | |
| rs58048037 | -- | 71.51% | ||
| rs55775132 | -- | A | 7.23% | |
| rs56934772 | -- | C | 9.40% | |
| rs57390839 | -- | 98.42% | ||
| rs1144710 | -- | A | 0.00% | |
| rs11617859 | -- | T | 0.88% | |
| rs11628905 | -- | 97.82% | ||
| rs117322572 | -- | T | 0.76% | |
| rs11758316 | -- | G | 11.50% | |
| rs118174802 | -- | T | 1.10% | |
| rs12203592 | -- | T | 3.67% | |
| rs12239076 | -- | G | 26.60% | |
| rs1264350 | -- | 95.73% | ||
| rs12912427 | -- | G | 19.09% | |
| rs12972593 | -- | 47.24% | ||
| rs1369639 | -- | 90.69% | ||
| rs180826669 | -- | T | 0.12% | |
| rs185236232 | -- | G | 0.12% | |
| rs188276406 | -- | C | 0.20% | |
| rs190788988 | -- | T | 0.14% | |
| rs191291131 | -- | T | 0.02% | |
| rs191805855 | -- | G | 0.16% | |
| rs192531874 | -- | 0.00% | ||
| rs193183075 | -- | T | 0.06% | |
| rs200814246 | -- | 0.00% | ||
| rs201820102 | -- | C | 0.00% | |
| rs202220630 | -- | 74.66% | ||
| rs2078387 | -- | 30.95% | ||
| rs28415045 | -- | 69.43% | ||
| rs28671668 | -- | 61.20% | ||
| rs2894254 | -- | G | 1.96% | |
| rs3130614 | -- | A | 2.60% | |
| rs3130976 | -- | C | 19.59% | |
| rs3131115 | -- | T | 32.69% | |
| rs3132451 | -- | C | 13.60% | |
| rs3132580 | -- | 96.17% | ||
| rs3132649 | -- | 93.71% | ||
| rs35724443 | -- | 90.32% | ||
| rs41317102 | -- | 90.62% | ||
| rs4143333 | -- | G | 3.95% | |
| rs4714034 | -- | T | 57.55% | |
| rs476080 | -- | T | 5.35% | |
| rs5005856 | -- | G | 43.53% | |
| rs519417 | -- | A | 3.25% | |
| rs59614521 | -- | T | 18.53% | |
| rs62035769 | -- | 51.58% | ||
| rs628839 | -- | 32.97% | ||
| rs75561433 | -- | A | 2.72% | |
| rs75570604 | -- | C | 2.10% | |
| rs75853901 | -- | G | 0.06% | |
| rs77704860 | -- | A | 17.49% | |
| rs77937677 | -- | A | 7.33% | |
| rs78529895 | -- | G | 6.39% | |
| rs803141 | -- | T | 32.31% | |
| rs9272729 | -- | 92.31% | ||
| rs9853827 | -- | T | 31.63% | |
| rs140328462 | -- | A | 3.21% | |
| rs112004685 | -- | A | 0.00% | |
| rs10191743 | -- | T | 91.81% | |
| rs142065142 | -- | 0.00% | ||
| rs142438673 | -- | 97.60% | ||
| rs145553345 | -- | C | 1.36% | |
| rs149851565 | -- | 88.76% | ||
| rs151305263 | -- | A | 0.06% | |
| rs16882975 | -- | T | 0.82% | |
| rs16891982 | -- | G | 27.50% | |
| rs10859273 | -- | T | 21.43% | |
| rs11097129 | -- | G | 19.13% | |
| rs113042278 | -- | 92.07% | ||
| rs146907294 | -- | A | 0.22% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
Authors: Aponte JL, Chiano MN, Yerges-Armstrong LM, Hinds DA, Tian C, Gupta A, Guo C, Fraser DJ, Freudenberg JM, Rajpal DK, Ehm MG, Waterworth DM
Study sample: 73,265 individuals (european ancestry)
