Traits - Genetic associations studied in sleep-breathing research
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Obstructive sleep apnea is a condition where the upper airway repeatedly narrows or collapses during sleep, causing pauses in breathing.
GWAS work has identified variants linked to airway anatomy, body fat distribution, and respiratory control that contribute to apnea risk.
This result reflects research-level variation in airway and breathing biology and is not a sleep study or a clinical diagnosis.
Body weight, neck size, jaw structure, alcohol, sedatives, sleep position, and age have a major impact on actual sleep apnea.
Research summary, not an individual result
This trait is presented as population-level genetic research rather than an individual Low/High verdict, because the science behind it is either too preliminary, too easily misread as a diagnosis, or too sensitive to responsibly reduce to a single badge.
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Review the genes, tested markers and supporting research.
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs9937053 | GA | A | 43.00% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
05/06/2021 Eur Respir J
Authors: Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mägi R, Mäkitie A, Salomaa V, Bachour A, Tuomi T, , Palotie A, Palotie T, Ripatti S
Study sample: 959,564 individuals (european, nr ancestry)
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