Skip to results

Traits explorer / Individual report

Movement during sleep

Sleep Patterns

Movement during sleep refers to how restless or still a person tends to be during the night, including periodic movements detected in sleep research.

Variants linked to dopaminergic signaling and iron handling have been associated with sleep-related movement traits, including those overlapping with restless legs research.

This result reflects research-level variation in sleep-movement biology and is not a diagnosis of a sleep movement disorder.

Sleep environment, caffeine, alcohol, medications, iron status, stress, and underlying health conditions also affect nighttime movement.

All traits Compare samples

Selected sample: Demo Report
Report markers: 3 SNP entries
Genes: 1
Research: 1 study

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance. Find more information at this link

Your report

Genetic tendency

Slightly increased tendency of developing restless legs syndrome

Very Low Very High

Was this result accurate for you?

Evidence and coverage

Confidence score

Very high

Read the evidence rating alongside the markers detected in your file. Confidence and tendency describe different aspects of this report.

Markers detected3 / 3100% coverage of report entries

Trait influence breakdown

Genetic 70% 70% Environment 30% 30%

Explore the evidence

Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data

SNP: A specific genetic marker relevant to this trait.
Genotype: The DNA letters reported at a marker location.
Variant allele: The alternative DNA sequence at the SNP site.
Variant allele frequency: The reported percentage of the reference population carrying this variant.
Variant found: Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

BTBD9

This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]

GeneCards

Chromosome: 6
Start: 38,168,451
End: 38,640,541
Build: HG19

Associated SNPs 1 / 1 detected

Associated markers for BTBD9
SNP	Genotype	Ref. allele	Variant allele	Frequency	Status
rs3923809	AG	A	G	39.66%	Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNP	Chromosome	Genotype	Variant allele	Frequency
rs3923809	6	AG	G	39.66%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD

Evidence

Statistical significance

09/01/2014

Authors: Moore H, Winkelmann J, Lin L, Finn L, Peppard P, Mignot E