Two genetic loci associated with ankle injury
Evidence Very strong scientific evidence
Authors: Kim SK, Kleimeyer JP, Ahmed MA, Avins AL, Fredericson M, Dragoo JL, Ioannidis JPA
Study sample: 83,264 individuals (european ancestry)
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Ankle injury susceptibility
Physical PerformanceAnkle injuries (sprains and ligament damage) are among the most common musculoskeletal injuries in sport.
GWAS work has identified variants near collagen and elastin genes (such as COL1A1 and COL5A1) linked to ankle injury susceptibility.
This result reflects research-level variation in connective tissue biology and is not an injury-risk diagnosis.
Sport type, footwear, surface, prior injury, balance training, fatigue, and warm-up have a major impact on actual ankle injury risk.
- Selected sample
- Demo Report
- Report markers
- 42 SNP entries
- Genes
- 0
- Research
- 1 study
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Behind this report
Review the genes, tested markers and supporting research.
SNPs tested
These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.
| SNP | Chromosome | Genotype | Variant allele | Frequency |
|---|---|---|---|---|
| rs35100037 | CT | T | 13.56% | |
| chr12:117470925 | -- | 0.00% | ||
| chr2:21806304 | -- | 0.00% | ||
| chr21:47156779 | -- | 1.10% | ||
| rs10506913 | -- | G | 10.00% | |
| rs115005126 | -- | C | 0.96% | |
| rs1167832 | -- | 81.81% | ||
| rs117724125 | -- | T | 1.66% | |
| rs12489876 | -- | A | 0.98% | |
| rs13259692 | -- | G | 7.17% | |
| rs13286037 | -- | A | 2.50% | |
| rs139095264 | -- | A | 1.36% | |
| rs140053818 | -- | C | 0.70% | |
| rs142347570 | -- | G | 1.26% | |
| rs149163456 | -- | T | 1.86% | |
| rs1569733 | -- | C | 94.09% | |
| rs1634423 | -- | T | 41.15% | |
| rs187271145 | -- | A | 1.52% | |
| rs270481 | -- | A | 19.23% | |
| rs2718798 | -- | 46.55% | ||
| rs34308817 | -- | T | 3.67% | |
| rs34324672 | -- | T | 5.45% | |
| rs35619804 | -- | G | 70.43% | |
| rs3803452 | -- | C | 5.07% | |
| rs3927971 | -- | 50.64% | ||
| rs413117 | -- | 36.82% | ||
| rs4340940 | -- | 0.16% | ||
| rs56118664 | -- | G | 0.58% | |
| rs61656020 | -- | 79.87% | ||
| rs62182422 | -- | T | 1.90% | |
| rs62187073 | -- | T | 1.90% | |
| rs62309831 | -- | A | 27.34% | |
| rs67227314 | -- | T | 7.49% | |
| rs7082617 | -- | 53.49% | ||
| rs72797642 | -- | G | 1.98% | |
| rs73208003 | -- | T | 0.90% | |
| rs73210044 | -- | A | 0.78% | |
| rs74576663 | -- | G | 37.22% | |
| rs7459609 | -- | 10.06% | ||
| rs75670712 | -- | C | 6.69% | |
| rs78681719 | -- | G | 1.60% | |
| chr10:17257254 | -- | 0.00% |
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.
Research studies
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
DEMO
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