Traits - Muscular endurance

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Muscular endurance

Physical Performance

Muscular endurance refers to a muscle's ability to sustain repeated contractions before fatiguing. It depends partly on muscle fiber composition and aerobic capacity.

GWAS and candidate-gene work has identified variants linked to endurance traits, including those near ACTN3 and PPARGC1A.

This result reflects research-level variation in endurance biology and is not a fitness test.

Training, age, body composition, nutrition, sleep, hydration, and recovery strongly shape actual muscular endurance.

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Demo Report
Report markers
3 SNP entries
Genes
1
Research
4 studies
Your report

Genetic tendency

Slightly increased performance in endurance sports

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Behind this report

Review the genes, tested markers and supporting research.

Genes analyzed

Gene summaries include genomic locations and associated markers. A detected genotype does not by itself indicate a health condition.

Understanding the data
SNP
A specific genetic marker relevant to this trait.
Genotype
The DNA letters reported at a marker location.
Variant allele
The alternative DNA sequence at the SNP site.
Variant allele frequency
The reported percentage of the reference population carrying this variant.
Variant found
Whether the variant was detected in your DNA file.

1 of 1 genes have detected genotypes.

PPARA

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

GeneCards
Chromosome
22
Start
46,150,521
End
46,243,756
Build
HG19
Associated SNPs 1 / 1 detected
Associated markers for PPARA
SNPGenotype Ref. alleleVariant alleleFrequencyStatus
rs4253778 CG GC27.42%Detected

SNPs tested

These are the unique genetic markers analyzed for this trait. Genotypes showing "--" were not identified in your DNA file. Report marker totals can include repeated study entries; this table shows each SNP once.

Genotypes and reported variant frequencies
SNPChromosomeGenotypeVariant alleleFrequency
rs425377822CGC27.42%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

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Coverage: 3/3 SNP entries detected (100%).

Reference: Human Genome Build 37 (HG19). Other testing companies may report using the opposite strand, requiring conversion for comparison.

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