Traits - Bone strength

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Bone strength

Physical Traits

Bone strength here refers to research on inherited differences in fracture susceptibility, including stress fractures from repeated load.

GWAS work has identified variants linked to bone density, bone geometry, and collagen biology that affect fracture risk.

This result reflects research-level variation in bone biology and is not a clinical fracture-risk assessment.

Training load, calcium and vitamin D, hormones, body weight, footwear, surface, and recovery also strongly influence actual stress-fracture risk.

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Genetic tendency

Average genetic tendency

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Review the genes, tested markers and supporting research.

Research studies

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

2019 Feb Nat Genet

Authors: Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, , Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB

Study sample: 426,824 individuals (european ancestry)

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Coverage: 0/0 SNP entries detected (0%).

Reference: Human Genome Build 37 (HG19). Other testing companies may report using the opposite strand, requiring conversion for comparison.

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