Behavioral Response

Genetic associations studied in metabolic-syndrome research

Metabolic syndrome is a research and clinical cluster of risk factors including abdominal obesity, high blood pressure, abnormal lipids, and elevated blood glucose.

GWAS work has identified many variants linked to its individual components, with overlap across diabetes, lipid, and blood pressure traits.

This result reflects research-level variation across the metabolic syndrome trait cluster and is not a clinical diagnosis.

Diet, physical activity, weight, sleep, smoking, alcohol, and medications all strongly affect actual metabolic syndrome status.

3 SNPs

1 Study

Sep 23, 2026

DEMO REPORT

Research Summary

What This Trait Studies

This section explains the population-level genetic research behind this trait. It is not an individual diagnosis or prediction.

Research summary, not an individual result

This trait is presented as population-level genetic research rather than an individual Low/High verdict, because the science behind it is either too preliminary, too easily misread as a diagnosis, or too sensitive to responsibly reduce to a single badge.

3 Genetic markers studied

3 Detected in your data

1 Gene analyzed

1 Research study

Not an individual prediction. This section summarizes population-level genetic research. It is not a personal diagnosis, a screening result, or a claim about you specifically. If this topic is a health, behavioral, or wellbeing concern for you, please talk with a qualified professional rather than relying on this genetic report.

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Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

APOA5 GeneCards

The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Genomic Location

Chr 11 Start: 116,789,367 End: 116,792,420 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs662799	A A	G	A	83.71%	Detected
Your Genotype AA Reference Allele G Variant Allele A Population Frequency 83.71% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs662799	11	AA	A	83.71%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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