Ancestry Publications

I. D. Ivanovsky, S. A. Polyakov, M. A. Filippova et al.

Molecular Biology

Russia

Tavares Gustavo Medina, GM Missaggia, Bruna Oliveira BO et al.

Genetics and molecular biologyGenet Mol BiolGenetic insights into the peoples who shaped the American continent.e20250244e20250244e2025024410.1590/1678-4685-GMB-2025-0244S1415-47572026000500107The initial peopling of America left a deep genetic legacy in Indigenous peoples and their admixed descendants. This narrative review recenters studies involving Indigenous populations and, inspired by the work of Francisco M. Salzano and Darcy Ribeiro's historical and cultural framework, adopts the working notions of "witness," "introduced," "transplanted," and "new" genetic signatures. We first clarify terminology to avoid neocolonial bias, using America to denote the continent and Native American to refer to all Indigenous peoples of America, and then synthesize the literature on initial peopling, post-contact demography, and natural selection, with particular emphasis on Brazil. We also present an illustrative example drawn from ongoing research conducted by our group, using genome editing to investigate a candidate adaptive allele in the context of high-altitude adaptation. Finally, we connect evolutionary history to contemporary health, highlighting mitonuclear interactions, dietary transitions, and pathogen exposures that may modulate disease risk, with implications for precision public health. Collectively, this review showcases ancestry-aware approaches tailored to Native American contexts and demonstrates why models developed elsewhere should not be uncritically extrapolated to America, advancing a continent-wide, Brazil-anchored perspective on Indigenous resilience and scientific significance.TavaresGustavo MedinaGM0000-0002-2015-167XUniversidade Federal do Rio Grande do Sul, Instituto de Biociências, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Laboratório de Evolução Humana e Molecular (LEHM), Porto Alegre, RS, Brazil.MissaggiaBruna OliveiraBO0000-0001-9431-530XUniversidade Federal do Rio Grande do Sul, Instituto de Biociências, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Laboratório de Evolução Humana e Molecular (LEHM), Porto Alegre, RS, Brazil.Sede da Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ancestralidade Genômica Brasileira (AncesGen), Porto Alegre, RS, Brazil.LimaThaynaraT0009-0005-2772-5356Universidade Federal do Rio Grande do Sul, Instituto de Biociências, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Laboratório de Evolução Humana e Molecular (LEHM), Porto Alegre, RS, Brazil.Sede da Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ancestralidade Genômica Brasileira (AncesGen), Porto Alegre, RS, Brazil.Marcano-RuizMarianaM0000-0001-6150-2942Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório Basic Research and Advanced Investigation in Neuroscience (BRAIN), Porto Alegre, RS, Brazil.MesquitaMaria Thereza SchmittMTS0009-0000-1257-9281Universidade Federal do Rio Grande do Sul, Instituto de Biociências, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Laboratório de Evolução Humana e Molecular (LEHM), Porto Alegre, RS, Brazil.BaldoGuilhermeG0000-0003-1598-5861Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório de Células, Tecidos e Genes (CTG), Porto Alegre, RS, Brazil.DornMárcioM0000-0001-8534-3480Universidade Federal do Rio Grande do Sul, Centro de Biotecnologia (CBiot), Instituto de Informática (INF), Departamento de Informática Teórica, Structural Bioinformatics and Computational Biology Lab, Porto Alegre, RS, Brazil.Sede da Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ancestralidade Genômica Brasileira (AncesGen), Porto Alegre, RS, Brazil.HünemeierTábitaT0000-0002-3156-2079Universidade de São Paulo, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, São Paulo, SP, Brazil.Universitat Pompeu Fabra, Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva, Barcelona, Spain.BortoliniMaria CátiraMC0000-0003-0598-3854Universidade Federal do Rio Grande do Sul, Instituto de Biociências, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Laboratório de Evolução Humana e Molecular (LEHM), Porto Alegre, RS, Brazil.Sede da Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ancestralidade Genômica Brasileira (AncesGen), Porto Alegre, RS, Brazil.engJournal Article20260403BrazilGenet Mol Biol1008835901415-4757Conflict of Interest: The authors declare that there is no conflict of interest that could be perceived as prejudicial to the impartiality of the reported research.202510312026222026470322026470312026461822202643epublish41941864PMC1306310810.1590/1678-4685-GMB-2025-0244S1415-47572026000500107Acuña-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hünemeier T, Moreno-Estrada A, Ortiz-López MG, Villamil-Ramírez H, León-Mimila P. 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Borda Victor, V Caceres, Omar O et al.

Communications biology

Peru

Yang Xiaomin, X Zou, Xinyue X et al.

Molecular biology and evolution

China

Lefeuvre Maël, M Marsolier, Marie-Claude MC et al.

Genome biology

Singh Vanya, V Basu Mallick, Chandana C et al.

American journal of human biology : the official journal of the Human Biology CouncilAm J Hum BiolAdmixture and Genetic Connectivity: Autosomal Insights Into Indo-Aryan Speakers at the Eastern Edge of the Indian Subcontinent.e70245e7024510.1002/ajhb.70245Assam serves as a melting pot where various ethnicities converge, shaped by its strategic location bordering the six northeastern states and neighboring countries. This study examines the genomic ancestry of Indo-Aryan speakers in Assam, a region at the eastern edge of the Indian subcontinent known for its diverse linguistic and cultural influences. Principal Components Analysis (PCA) revealed that Assamese Indo-Aryans cluster closely with Bangladeshi Indo-Aryans, diverging from the typical South Asian genetic continuum. This group shows significant ancestral influences from East and Southeast Asia. Outgroup f3 statistics indicated that Assamese Indo-Aryans exhibit greater genetic drift in relation to other Indo-Aryan populations, particularly the Harijan and Kol groups from the Ganga plain, rather than with geographically closer Bengali or Nyishi populations. Haplotype-based fine-structure and identity by descent (IBD) analyses confirmed a close genetic affinity with Bangladeshi Indo-Aryans, along with notable connections to Harijan and Kol populations. The low levels of Runs of Homozygosity (RoH) suggest a high degree of genetic diversity, most likely due to a result of admixture and a large effective population size. Admixture events are estimated to have occurred 55 to 61 generations ago, indicating a composition of 76% Indian ancestry and 24% East/Southeast Asian ancestry. These findings, with enhanced resolution, suggest a reconsideration of the previous assumption that Northeast India served as a genetic barrier. Instead, they appear to support its role as a corridor facilitating bidirectional gene flow between South and East/Southeast Asia. Furthermore, the coexistence of diverse linguistic affiliations of ethnic groups in this region reflects in their ancestry patterns. These findings highlight the complex interplay of geography, language, and genetic exchange in the region.© 2026 Wiley Periodicals LLC.SinghVanyaV0000-0002-2832-7393Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Basu MallickChandanaC0000-0001-9459-2710Centre for Genetic Disorders, Banaras Hindu University, Varanasi, Uttar Pradesh, India.ChatterjeeMadhumatiM0000-0002-0136-6149Department of Anthropology, Dr APJ Abdul Kalam Government College, Kolkata, India.TamangRakeshR0000-0001-9873-3066Department of Zoology, University of Calcutta, Kolkata, West Bengal, India.DesaiShaileshS0000-0002-1812-5106Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghPrajjval PratapPP0000-0002-8081-5634Laboratory of Genomics and Profiling Applications, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.MishraRahul KumarRK0000-0003-2608-7856Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur, India.PandeyRudra KumarRK0000-0002-0995-923XGyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.MishraRitushaR0000-0003-4533-0727Department of Radiotherapy and Radiation Medicines, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghAshishA0000-0002-6819-2905Dr. Lalji Singh Research Centre, Kalwari, Jaunpur, Uttar Pradesh, India.SuravajhalaPrashanthP0000-0002-8535-278XDepartment of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, India.BandyopadhyayArup RatanAR0000-0003-3119-0022Department of Anthropology, University of Calcutta, Kolkata, West Bengal, India.ChaubeyGyaneshwerG0000-0003-2899-3852Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.eng6031BHU IoE incentive grant BHU2021-6389Indian Council of Medical Research2021-11289Indian Council of Medical ResearchDepartment of Zoology, BHUJournal ArticleUnited StatesAm J Hum Biol89150291042-0533IMHumansIndiaHaplotypesGene FlowPrincipal Component AnalysisGenetic VariationEthnicitygeneticsGenetics, PopulationAsian PeoplegeneticsIndo‐AryanNortheast IndiaTibeto‐Burmanadmixtureautosomesgeneflow20263520251062026310202632071120263207102026320213ppublish4185809810.1002/ajhb.70245References

India

Zhang Ganyu, G Zhao, Chaohong C et al.

Current biology : CB

East Asia

Chen Yaen, Y Velazquez-Arcelay, Keila K et al.

Molecular biology and evolution

Psonis Nikolaos, N Tabakaki, Eugenia E et al.

Genome biology

Tao Le, L Xie, Ying Y et al.

Molecular biology and evolution

Luo Lisiteng, L Liu, Yanling Y et al.

BMC biology

Alvin Cengnata, C Pei-Mei, Tham T et al.

Annals of human geneticsAnn Hum GenetDissecting the Genetic Affinity Between the Orang Asli and Southeast Asian Native Populations.1121-1210.1111/ahg.70005Southeast Asia (SEA) is a region with enriched human diversity and complex population history. Despite numerous small-scale population genetics studies being carried out, the map of human migration in this landmass remains fragmentary. Notably, the genetic affinities of the Orang Asli from Peninsular Malaysia and other SEA natives have not been comprehensively assessed.In this study, publicly available genotypic datasets were gathered and imputed. The genetic relationships and ancestry make-up of 19 SEA native populations, covering Peninsular Malaysia, Indonesia, Papua New Guinea, the Philippines, Vietnam, and Andaman, were comprehended and benchmarked with 14 global populations.With ∼20 million SNPs coverage, we provided supporting evidence to (i) a possible ancient genetic link between the Andamanese, Papuan and the Philippines and Peninsular Negrito; (ii) gene flow from the ancestors of Andamanese to Papuan, and the Negrito from Peninsular Malaysia and the Philippines; (iii) different genetic structures between the island SEA (iSEA) and mainland (mSEA) populations; (iv) close genetic affinity between the Proto-Malay Seletar with the iSEA populations and (v) close genetic affinity between the Senoi Mah Meri with the Proto-Malays.To our knowledge, this study reported the highest genomic sequence coverage and the most comprehensive SEA native populations covered thus far. Our results not only have provided strong supporting evidence to the earlier hypothesis, but also novel insights into the genetic diversity of the SEA native populations.© 2025 University College London (UCL) and John Wiley & Sons Ltd.AlvinCengnataCFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.Pei-MeiThamTDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Hoi-ThungFooFDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Calista Zhe-QingChanCDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.XinLeeLDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.Renee Lay-HongLimLFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.LianDengDState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China.ShuhuaXuXState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China.Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China.School of Life Science and Technology, ShanghaiTech University, Shanghai, China.Boon-PengHohHDivision of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia.engFRGS/1/2021/STG01/UCSI/01/1Ministry of Higher Education (MOHE) Malaysia32030020National Natural Science Foundation of China32288101National Natural Science Foundation of China32270665National Natural Science Foundation of ChinaJournal Article20250629EnglandAnn Hum Genet04166610003-4800Orang Asli peopleIMHumansAsia, SoutheasternGene FlowGenetic VariationGenetics, PopulationHuman MigrationMalaysiaPolymorphism, Single NucleotideSoutheast Asian PeopleOrang AsliSoutheast Asiagenetic affinitygenome variationsnatives2025662025111202561120251212720202571462025630233ppublish4058339610.1111/ahg.70005References