Four ancient individuals from Andrés have yielded DNA results—an extremely small sample that requires cautious interpretation. Two of the male-line (Y-DNA) results belong to haplogroup Q, a lineage widespread among Indigenous peoples of the Americas and commonly recovered in pre-contact Caribbean contexts. On the maternal side, mitochondrial haplogroups A (two instances, one specified as A2) and C (one instance) were observed; these are part of the suite of founding Native American maternal lineages (A, B, C, D, and X) distributed across the hemisphere.
Taken together, the genetic signatures from Andrés are consistent with Indigenous American ancestry typical of Ceramic Period Caribbean populations. The presence of haplogroup Q on the Y-chromosome can reflect paternal continuity stretching back to initial peopling events of the Americas, while mtDNA A and C point to maternal lineages also common in northern South America and the Antilles.
However, with only four samples the ability to resolve finer-scale questions—such as precise source regions (e.g., Arawakan-speaking areas of South America), degrees of genetic continuity through time, or patterns of sex-biased migration—is limited. Archaeogenomic work combining larger sample sizes, genome-wide data, and robust radiocarbon frameworks will be necessary to test hypotheses about migration routes, kinship structures, and genetic links between Andrés, neighboring islands, and mainland source populations.