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DNA

DNA

Illustration of NUMTs integrating into the nuclear genome and impacting gene regulation
DNA

Archaic NUMTs reshape modern DNA function in humans

A large-scale study catalogs thousands of nuclear mitochondrial DNA segments (NUMTs) and uncovers five archaic-derived insertions that modulate gene regulation and chromatin — revealing a new layer of ancestry and genome function in modern humans.

March 5, 2026 6 min