This service imputes any RAW DNA data file (23andme, Ancestry, FTDNA, MyHeritage, LivingDNA, …) from 700K SNPs to 30 millions SNPs.
The imputation is performed using BEAGLE 5.2, BCFTOOLS and the 1000Genomes human reference panel. You will received the following files and report:
The imputation process only imputes the chromosomes 1-22. MTDNA and YDNA cannot be imputed.
Once the results are ready, you will receive an email containing a link to the imputed file and you will find the ancestry & traits report in your account.
What are the differences between non-imputed and an imputed file ancestry & traits reports?
Your Recent ancestry might be similar if you already have a relatively homogeneous recent ancestry. This is, if all your known ancestors are from the same ethnic population group in the last 300 years, there would be just subtle differences. The Shared Origins report might show a further detailed ancient connection between your DNA and other world populations. You and those listed populations may share the same roots thousands of years, but it doesn't mean you have an ancestor from these populations.
Will the traits report improve after imputing my RAW DNA file?
Yes, your traits report also gets an improvement thanks to the extra SNPs. There you might find more traits that were inconclusive with your original RAW file.
Will the neanderthal report improve after imputing my RAW DNA file?
Yes, your neanderthal traits report also gets an improvement thanks to the extra SNPs. There you might find more traits that were inconclusive with your original RAW file.
Where can I upload the imputed RAW file?
This file can be uploaded to Gedmatch, Promethease and GenVue. As well, it can be used in Admixture Studio.
DISCLAIMER: Imputation service increases the number of SNPs using a statistical approach prone to miscall from 1% to 5% of the genotypes.. So, we recommend not to use it for health predictions. So, please, if you upload your imputed results to a website that offers health predictions, take into account there could be some false-positives or negatives.
More information about the DNA imputation: Ancestry.com article explaining DNA imputation.