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GWAS Study

Genome-wide analysis of genetic loci associated with Alzheimer disease.

Seshadri S, Fitzpatrick AL, Ikram MA et al.

20460622 PubMed ID
GWAS Study Type
45647 Participants
284 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SS
Seshadri S
FA
Fitzpatrick AL
IM
Ikram MA
DA
DeStefano AL
GV
Gudnason V
BM
Boada M
BJ
Bis JC
SA
Smith AV
CM
Carassquillo MM
LJ
Lambert JC
HD
Harold D
SE
Schrijvers EM
RR
Ramirez-Lorca R
DS
Debette S
LW
Longstreth WT
JA
Janssens AC
PV
Pankratz VS
DJ
Dartigues JF
HP
Hollingworth P
AT
Aspelund T
HI
Hernandez I
BA
Beiser A
KL
Kuller LH
KP
Koudstaal PJ
DD
Dickson DW
TC
Tzourio C
AR
Abraham R
AC
Antunez C
DY
Du Y
RJ
Rotter JI
AY
Aulchenko YS
HT
Harris TB
PR
Petersen RC
BC
Berr C
OM
Owen MJ
LJ
Lopez-Arrieta J
VB
Varadarajan BN
BJ
Becker JT
RF
Rivadeneira F
NM
Nalls MA
GN
Graff-Radford NR
CD
Campion D
AS
Auerbach S
RK
Rice K
HA
Hofman A
JP
Jonsson PV
SH
Schmidt H
LM
Lathrop M
MT
Mosley TH
AR
Au R
PB
Psaty BM
UA
Uitterlinden AG
FL
Farrer LA
LT
Lumley T
RA
Ruiz A
WJ
Williams J
AP
Amouyel P
YS
Younkin SG
WP
Wolf PA
LL
Launer LJ
LO
Lopez OL
VD
van Duijn CM
BM
Breteler MM
Chapter II

Abstract

Summary of the research findings

Context: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).

973 incident AD cases, 2,033 prevalent AD cases, 22,604 controls of European and Hispanic ancestry

Chapter III

Study Statistics

Key metrics and study information

45647
Total Participants
GWAS
Study Type
Yes
Replicated
6,505 European ancestry cases, 13,532 European ancestry controls
Replication Participants
European, European, Hispanic or Latin American
Ancestry
Spain, France
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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