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GWAS Study

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

Sobrin L, Ripke S, Yu Y et al.

22705344 PubMed ID
GWAS Study Type
25664 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SL
Sobrin L
RS
Ripke S
YY
Yu Y
FJ
Fagerness J
BT
Bhangale TR
TP
Tan PL
SE
Souied EH
BG
Buitendijk GH
MJ
Merriam JE
RA
Richardson AJ
RS
Raychaudhuri S
RR
Reynolds R
CK
Chin KA
LA
Lee AY
LN
Leveziel N
ZD
Zack DJ
CP
Campochiaro P
SR
Smith RT
BG
Barile GR
HR
Hogg RE
CU
Chakravarthy U
BT
Behrens TW
UA
Uitterlinden AG
VD
van Duijn CM
VJ
Vingerling JR
BM
Brantley MA
BP
Baird PN
KC
Klaver CC
AR
Allikmets R
KN
Katsanis N
GR
Graham RR
IJ
Ioannidis JP
DM
Daly MJ
SJ
Seddon JM
Chapter II

Abstract

Summary of the research findings

Purpose: To investigate whether the 2 subtypes of advanced age-related macular degeneration (AMD), choroidal neovascularization (CNV), and geographic atrophy (GA) segregate separately in families and to identify which genetic variants are associated with these 2 subtypes.

1,775 European ancestry choroidal neovascularization cases, 4,134 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

25664
Total Participants
GWAS
Study Type
Yes
Replicated
4,515 European and unknown ancestry choroidal neovascularization cases, 15,240 European and unknown ancestry controls
Replication Participants
European, NR, European
Ancestry
U.S., Australia, Netherlands, U.K., France
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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