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GWAS Study

A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.

Chung S, Low SK, Zembutsu H et al.

24025145 PubMed ID
GWAS Study Type
1206 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CS
Chung S
LS
Low SK
ZH
Zembutsu H
TA
Takahashi A
KM
Kubo M
SM
Sasa M
NY
Nakamura Y
Chapter II

Abstract

Summary of the research findings

Introduction: Chemotherapy-induced alopecia is one of the most common adverse events caused by conventional cytotoxic chemotherapy, yet there has been very little progress in the prevention or treatment of this side effect. Although this is not a life-threatening event, alopecia is very psychologically difficult for many women to manage. In order to improve the quality of life for these women, it is important to elucidate the molecular mechanisms of chemotherapy-induced alopecia and develop ways to effectively prevent and/or treat it. To identify the genetic risk factors associated with chemotherapy-induced alopecia, we conducted a genome-wide association study (GWAS) using DNA samples from breast cancer patients who were treated with chemotherapy.

303 Japanese ancestry cases, 880 Japanese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

1206
Total Participants
GWAS
Study Type
Yes
Replicated
23 Japanese ancestry cases
Replication Participants
East Asian
Ancestry
Japan
Recruitment Country
Chapter IV

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