Genome-wide association study of chronic hepatitis B virus infection reveals a novel candidate risk allele on 11q22.3.
Al-Qahtani A, Khalak HG, Alkuraya FS et al.
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Hepatitis B virus (HBV) affects millions of people worldwide. While some people are able to clear the virus following the first encounter, those who develop chronic infection manifest remarkable clinical heterogeneity that ranges from asymptomatic carrier state to cirrhosis and hepatocellular carcinoma. Despite extensive studies, little is known about genetic host factors that influence the outcome of chronic HBV infection. Thus, we conducted this study to investigate the genetic risk of developing active liver disease among chronic carriers of HBV.
up to 305 Arab ancestry cases, 343 Arab ancestry controls
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