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GWAS Study

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Hirano A, Ohara T, Takahashi A et al.

26049409 PubMed ID
GWAS Study Type
17031 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HA
Hirano A
OT
Ohara T
TA
Takahashi A
AM
Aoki M
FY
Fuyuno Y
AK
Ashikawa K
MT
Morihara T
TM
Takeda M
KK
Kamino K
OE
Oshima E
OY
Okahisa Y
SN
Shibata N
AH
Arai H
AH
Akatsu H
IM
Ikeda M
IN
Iwata N
NT
Ninomiya T
MA
Monji A
KT
Kitazono T
KY
Kiyohara Y
KM
Kubo M
KS
Kanba S
Chapter II

Abstract

Summary of the research findings

Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations.

489 Japanese ancestry APOE-ε4 noncarrier cases, 6,463 Japanese ancestry APOE-ε4 noncarrier controls, 323 Japanese ancestry APOE-ε4 carrier cases, 1,484 Japanese ancestry APOE-ε4 carrier controls, 4 Japanese ancestry cases, 45 Japanese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

17031
Total Participants
GWAS
Study Type
Yes
Replicated
528 Japanese ancestry APOE-ε4 noncarrier cases, 5,824 Japanese ancestry APOE-ε4 noncarrier controls, 480 Japanese ancestry APOE-ε4 carrier cases, 1,364 Japanese ancestry APOE-ε4 carrier controls, 3 Japanese ancestry cases, 24 Japanese ancestry controls
Replication Participants
East Asian
Ancestry
Japan
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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