F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.
Tosto G, Fu H, Vardarajan BN et al.
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Abstract
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Objective: In the context of late-onset Alzheimer's disease (LOAD) over 20 genes have been identified but, aside APOE, all show small effect sizes, leaving a large part of the genetic component unexplained. Admixed populations, such as Caribbean Hispanics, can provide a valuable contribution because of their unique genetic profile and higher incidence of the disease. We aimed to identify novel loci associated with LOAD.
2,451 Caribbean Hispanic cases, 2,063 Caribbean Hispanic controls
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