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GWAS Study

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

van 't Hof FN, Ruigrok YM, Lee CH et al.

27418160 PubMed ID
GWAS Study Type
12601 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

V'
van 't Hof FN
RY
Ruigrok YM
LC
Lee CH
RS
Ripke S
AG
Anderson G
DA
de Andrade M
BA
Baas AF
BJ
Blankensteijn JD
BE
Böttinger EP
BM
Bown MJ
BJ
Broderick J
BP
Bijlenga P
CD
Carrell DS
CD
Crawford DC
CD
Crosslin DR
EC
Ebeling C
EJ
Eriksson JG
FM
Fornage M
FT
Foroud T
VU
von Und Zu Fraunberg M
FC
Friedrich CM
GE
Gaál EI
GO
Gottesman O
GD
Guo DC
HS
Harrison SC
HJ
Hernesniemi J
HA
Hofman A
II
Inoue I
JJ
Jääskeläinen JE
JG
Jones GT
KL
Kiemeney LA
KR
Kivisaari R
KN
Ko N
KS
Koskinen S
KM
Kubo M
KI
Kullo IJ
KH
Kuivaniemi H
KM
Kurki MI
LA
Laakso A
LD
Lai D
LS
Leal SM
LH
Lehto H
LS
LeMaire SA
LS
Low SK
MJ
Malinowski J
MC
McCarty CA
MD
Milewicz DM
MT
Mosley TH
NY
Nakamura Y
NH
Nakaoka H
NM
Niemelä M
PJ
Pacheco J
PP
Peissig PL
PJ
Pera J
RL
Rasmussen-Torvik L
RM
Ritchie MD
RF
Rivadeneira F
VR
van Rij AM
SR
Santos-Cortez RL
SA
Saratzis A
SA
Slowik A
TA
Takahashi A
TG
Tromp G
UA
Uitterlinden AG
VS
Verma SS
VS
Vermeulen SH
WG
Wang GT
HB
Han B
RG
Rinkel GJ
DB
de Bakker PI
Chapter II

Abstract

Summary of the research findings

Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs.

1,516 European ancestry intracranial aneurysm cases, 818 European ancestry abdominal aortic aneurysm cases, 760 European ancestry thoracic aortic aneurysm cases, 9,507 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

12601
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Finland, U.S., Netherlands
Recruitment Country
Chapter IV

AI-Generated Summary

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