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Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.

Klarin D, Emdin CA, Natarajan P et al.

28373160 PubMed ID
GWAS Study Type
185892 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KD
Klarin D
EC
Emdin CA
NP
Natarajan P
CM
Conrad MF
KS
Kathiresan S
Chapter II

Abstract

Summary of the research findings

UK Biobank is the world's largest repository for phenotypic and genotypic information for individuals of European ancestry. Here, we leverage UK Biobank to understand the inherited basis for venous thromboembolism (VTE), a leading cause of cardiovascular mortality.

3,290 European ancestry cases, 116,868 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

185892
Total Participants
GWAS
Study Type
Yes
Replicated
65,734 cases and controls (see Germain, 2015)
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

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