Menu
Currency
GWAS Study

Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use.

Marees AT, Hammerschlag AR, Bastarache L et al.

29758381 PubMed ID
GWAS Study Type
39148 Participants
47 Views
Scroll to explore
Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MA
Marees AT
HA
Hammerschlag AR
BL
Bastarache L
DK
de Kluiver H
VF
Vorspan F
VD
van den Brink W
SD
Smit DJ
DD
Denys D
GE
Gamazon ER
LR
Li-Gao R
BE
Breetvelt EJ
DG
de Groot MCH
GT
Galesloot TE
VS
Vermeulen SH
PJ
Poppelaars JL
SP
Souverein PC
KR
Keeman R
DM
de Mutsert R
NR
Noordam R
RF
Rosendaal FR
SN
Stringa N
MD
Mook-Kanamori DO
VI
Vaartjes I
KL
Kiemeney LA
DH
den Heijer M
VS
van Schoor NM
KO
Klungel OH
MD
Maitland-Van der Zee AH
SM
Schmidt MK
PT
Polderman TJC
VD
van der Leij AR
PD
Posthuma D
DE
Derks EM
Chapter II

Abstract

Summary of the research findings

Alcohol and tobacco use are heritable phenotypes. However, only a small number of common genetic variants have been identified, and common variants account for a modest proportion of the heritability. Therefore, this study aims to investigate the role of low-frequency and rare variants in alcohol and tobacco use.

13,640 individuals

Chapter III

Study Statistics

Key metrics and study information

39148
Total Participants
GWAS
Study Type
Yes
Replicated
367 cases, 25,141 controls
Replication Participants
Netherlands, U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

AI Summary In Progress

Our AI-generated summary of this publication is being prepared. Please check back soon.