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GWAS Study

Genome-wide association study and meta-analysis on alcohol-related liver cirrhosis identifies novel genetic risk factors.

Schwantes-An TH, Darlay R, Mathurin P et al.

32853455 PubMed ID
GWAS Study Type
14780 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

ST
Schwantes-An TH
DR
Darlay R
MP
Mathurin P
MS
Masson S
LS
Liangpunsakul S
MS
Mueller S
AG
Aithal GP
EF
Eyer F
GD
Gleeson D
TA
Thompson A
MB
Muellhaupt B
SF
Stickel F
SM
Soyka M
GD
Goldman D
LT
Liang T
LL
Lumeng L
PM
Pirmohamed M
NB
Nalpas B
JJ
Jacquet JM
MR
Moirand R
NP
Nahon P
NS
Naveau S
PP
Perney P
BG
Botwin G
HP
Haber PS
SH
Seitz HK
DC
Day CP
FT
Foroud TM
DA
Daly AK
CH
Cordell HJ
WJ
Whitfield JB
MT
Morgan TR
SD
Seth D
Chapter II

Abstract

Summary of the research findings

Background and aims: Only a minority of heavy drinkers progress to alcohol-associated cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie risk for ALC.

1,128 European ancestry cases, 849 European ancestry heavy-drinking controls

Chapter III

Study Statistics

Key metrics and study information

14780
Total Participants
GWAS
Study Type
Yes
Replicated
up to 2,369 European ancestry cases, up to 10,434 European ancestry heavy-drinking controls
Replication Participants
European
Ancestry
France, Germany, Switzerland, U.K., U.S., Australia
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

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