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GWAS Study

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

Yin X, Kim K, Suetsugu H et al.

33272962 PubMed ID
GWAS Study Type
208370 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

YX
Yin X
KK
Kim K
SH
Suetsugu H
BS
Bang SY
WL
Wen L
KM
Koido M
HE
Ha E
LL
Liu L
SY
Sakamoto Y
JS
Jo S
LR
Leng RX
ON
Otomo N
LV
Laurynenka V
KY
Kwon YC
SY
Sheng Y
SN
Sugano N
HM
Hwang MY
LW
Li W
MM
Mukai M
YK
Yoon K
CM
Cai M
IK
Ishigaki K
CW
Chung WT
HH
Huang H
TD
Takahashi D
LS
Lee SS
WM
Wang M
KK
Karino K
SS
Shim SC
ZX
Zheng X
MT
Miyamura T
KY
Kang YM
YD
Ye D
NJ
Nakamura J
SC
Suh CH
TY
Tang Y
MG
Motomura G
PY
Park YB
DH
Ding H
KT
Kuroda T
CJ
Choe JY
LC
Li C
NH
Niiro H
PY
Park Y
SC
Shen C
MT
Miyamoto T
AG
Ahn GY
FW
Fei W
TT
Takeuchi T
SJ
Shin JM
LK
Li K
KY
Kawaguchi Y
LY
Lee YK
WY
Wang Y
AK
Amano K
PD
Park DJ
YW
Yang W
TY
Tada Y
YK
Yamaji K
SM
Shimizu M
AT
Atsumi T
SA
Suzuki A
ST
Sumida T
OY
Okada Y
MK
Matsuda K
MK
Matsuo K
KY
Kochi Y
KL
Kottyan LC
WM
Weirauch MT
PS
Parameswaran S
ES
Eswar S
SH
Salim H
CX
Chen X
YK
Yamamoto K
HJ
Harley JB
OK
Ohmura K
KT
Kim TH
YS
Yang S
YT
Yamamoto T
KB
Kim BJ
SN
Shen N
IS
Ikegawa S
LH
Lee HS
ZX
Zhang X
TC
Terao C
CY
Cui Y
BS
Bae SC
Chapter II

Abstract

Summary of the research findings

Objective: Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations.

13,377 East Asian ancestry cases, 194,993 East Asian ancestry controls

Chapter III

Study Statistics

Key metrics and study information

208370
Total Participants
GWAS
Study Type
No
Replicated
East Asian
Ancestry
China, Japan, Republic of Korea
Recruitment Country
Chapter IV

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