The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.
Hanscombe KB, Persyn E, Traylor M et al.
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Abstract
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Cardiorespiratory fitness (CRF) and physical activity (PA) are well-established predictors of morbidity and all-cause mortality. However, CRF is not routinely measured and PA not routinely prescribed as part of standard healthcare. The American Heart Association (AHA) recently presented a scientific case for the inclusion of CRF as a clinical vital sign based on epidemiological and clinical observation. Here, we leverage genetic data in the UK Biobank (UKB) to strengthen the case for CRF as a vital sign and make a case for the prescription of PA.
70,783 European ancestry individuals
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