Inference of admixture in dogs from whole genome sequences.
Kislik Gregory, G Moore, Garrett G et al.
Publication Details
Comprehensive information about this research publication
Abstract
Summary of the research findings
Understanding the genetic architecture of domestic dogs provides unique insights into the processes of domestication, breed formation, and the genetic basis of complex traits and diseases. Dog populations, characterized by their diverse morphologies and behaviors, also exhibit extensive evidence of historical and ongoing admixture. This widespread mixing, driven by both natural migration and selective breeding practices, has profoundly shaped the genomic landscape of modern dog breeds. Though global admixture has been extensively estimated in human population studies, where the number of subgroups is typically limited, there has been more limited analysis in canines, where there may be dozens of ancestral groups, or breeds.Here we present a procedure for estimating global admixture in dogs from whole genome sequence data using SCOPE. We created a reference population of 65 dog breeds that included 349 individuals, from which we determined breed-informative SNPs. We demonstrate that SCOPE can accurately infer breed composition in both simulated and real admixed samples, even at low sequencing depths. We also characterized the genetic similarity between our reference dog breeds and recovered previously reported relationships.This approach allows us to identify the strength of the genetic signature of breeds and place error bounds on admixture estimates. It also provides evidence that admixture can be accurately inferred in subjects that may originate from multiple ancestral populations.
AI-Generated Summary
AI-generated by DNAGENICSIndependent AI summary of ancestry and genetic findings from the published study
Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.