A high-coverage Neandertal genome from Vindija Cave in Croatia
Prüfer K, de Filippo C, Grote S et al.
Publication Details
Comprehensive information about this research publication
Abstract
Summary of the research findings
To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
Ancient DNA Samples
5 ancient DNA samples referenced in this publication
| Sample ID | Date/Era | Country | Locality | Sex | mtDNA | Y-DNA |
|---|---|---|---|---|---|---|
| Vindija | 43500 BCE | Croatia | Vindija Cave | F | ND1b1a1b1 |
|
| I0001 | 6221 BCE | Luxembourg | Echternach | M | U5b1a |
I-V4921 |
| Altai | 128050 BCE | Russia | Denisova Cave. Altai | F | ND1a |
|
| Denisova | 74250 BCE | Russia | Denisova Cave. Altai | F | DN1a1 |
|
| Ust_Ishim | 43980 BCE | Russia | Ust'-Ishim. Siberia | M | R* |
K-M2308 |
Analysis
Comprehensive review of ancestry and genetic findings
Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.