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Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Wang TJ, Zhang F, Richards JB et al.

20541252 PubMed ID
GWAS Study Type
33996 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

WT
Wang TJ
ZF
Zhang F
RJ
Richards JB
KB
Kestenbaum B
VM
van Meurs JB
BD
Berry D
KD
Kiel DP
SE
Streeten EA
OC
Ohlsson C
KD
Koller DL
PL
Peltonen L
CJ
Cooper JD
OP
O'Reilly PF
HD
Houston DK
GN
Glazer NL
VL
Vandenput L
PM
Peacock M
SJ
Shi J
RF
Rivadeneira F
MM
McCarthy MI
AP
Anneli P
DB
de Boer IH
MM
Mangino M
KB
Kato B
SD
Smyth DJ
BS
Booth SL
JP
Jacques PF
BG
Burke GL
GM
Goodarzi M
CC
Cheung CL
WM
Wolf M
RK
Rice K
GD
Goltzman D
HN
Hidiroglou N
LM
Ladouceur M
WN
Wareham NJ
HL
Hocking LJ
HD
Hart D
AN
Arden NK
CC
Cooper C
MS
Malik S
FW
Fraser WD
HA
Hartikainen AL
ZG
Zhai G
MH
Macdonald HM
FN
Forouhi NG
LR
Loos RJ
RD
Reid DM
HA
Hakim A
DE
Dennison E
LY
Liu Y
PC
Power C
SH
Stevens HE
JL
Jaana L
VR
Vasan RS
SN
Soranzo N
BJ
Bojunga J
PB
Psaty BM
LM
Lorentzon M
FT
Foroud T
HT
Harris TB
HA
Hofman A
JJ
Jansson JO
CJ
Cauley JA
UA
Uitterlinden AG
GQ
Gibson Q
JM
Järvelin MR
KD
Karasik D
SD
Siscovick DS
EM
Econs MJ
KS
Kritchevsky SB
FJ
Florez JC
TJ
Todd JA
DJ
Dupuis J
HE
Hyppönen E
ST
Spector TD
Chapter II

Abstract

Summary of the research findings

Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.

16,125 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

33996
Total Participants
GWAS
Study Type
Yes
Replicated
17,871 European ancestry individuals
Replication Participants
European
Ancestry
U.S., U.K., Sweden
Recruitment Country
Chapter IV

AI-Generated Summary

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