Menu
Currency
GWAS Study

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

Perera MA, Cavallari LH, Limdi NA et al.

23755828 PubMed ID
GWAS Study Type
965 Participants
56 Views
Scroll to explore
Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PM
Perera MA
CL
Cavallari LH
LN
Limdi NA
GE
Gamazon ER
KA
Konkashbaev A
DR
Daneshjou R
PA
Pluzhnikov A
CD
Crawford DC
WJ
Wang J
LN
Liu N
TN
Tatonetti N
BS
Bourgeois S
TH
Takahashi H
BY
Bradford Y
BB
Burkley BM
DR
Desnick RJ
HJ
Halperin JL
KS
Khalifa SI
LT
Langaee TY
LS
Lubitz SA
NE
Nutescu EA
OM
Oetjens M
SM
Shahin MH
PS
Patel SR
SH
Sagreiya H
TM
Tector M
WK
Weck KE
RM
Rieder MJ
SS
Scott SA
WA
Wu AH
BJ
Burmester JK
WM
Wadelius M
DP
Deloukas P
WM
Wagner MJ
MT
Mushiroda T
KM
Kubo M
RD
Roden DM
CN
Cox NJ
AR
Altman RB
KT
Klein TE
NY
Nakamura Y
JJ
Johnson JA
Chapter II

Abstract

Summary of the research findings

VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans.

533 African American individuals

Chapter III

Study Statistics

Key metrics and study information

965
Total Participants
GWAS
Study Type
Yes
Replicated
432 African American individuals
Replication Participants
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

AI Summary In Progress

Our AI-generated summary of this publication is being prepared. Please check back soon.