A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
Davies RW, Wells GA, Stewart AF et al.
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Abstract
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Recent genome-wide association studies (GWAS) have identified several novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial infarction risk. However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered.
7,123 European ancestry cases, 6,826 European ancestry controls
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