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GWAS Study

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.

Peters MJ, Broer L, Willemen HL et al.

22956598 PubMed ID
GWAS Study Type
16568 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PM
Peters MJ
BL
Broer L
WH
Willemen HL
EG
Eiriksdottir G
HL
Hocking LJ
HK
Holliday KL
HM
Horan MA
MI
Meulenbelt I
NT
Neogi T
PM
Popham M
SC
Schmidt CO
SA
Soni A
VA
Valdes AM
AN
Amin N
DE
Dennison EM
EN
Eijkelkamp N
HT
Harris TB
HD
Hart DJ
HA
Hofman A
HF
Huygen FJ
JK
Jameson KA
JG
Jones GT
LL
Launer LJ
KH
Kerkhof HJ
DK
de Kruijf M
MJ
McBeth J
KM
Kloppenburg M
OW
Ollier WE
OB
Oostra B
PA
Payton A
RF
Rivadeneira F
SB
Smith BH
SA
Smith AV
SL
Stolk L
TA
Teumer A
TW
Thomson W
UA
Uitterlinden AG
WK
Wang K
VW
van Wingerden SH
AN
Arden NK
CC
Cooper C
FD
Felson D
GV
Gudnason V
MG
Macfarlane GJ
PN
Pendleton N
SP
Slagboom PE
ST
Spector TD
VH
Völzke H
KA
Kavelaars A
VD
van Duijn CM
WF
Williams FM
VM
van Meurs JB
Chapter II

Abstract

Summary of the research findings

Background and objectives: Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP.

1,308 European ancestry female cases, 5,791 European ancestry female controls

Chapter III

Study Statistics

Key metrics and study information

16568
Total Participants
GWAS
Study Type
Yes
Replicated
1,480 European ancestry female cases, 7,989 European ancestry female controls
Replication Participants
European
Ancestry
Netherlands, U.K., U.S., Iceland, Germany
Recruitment Country
Chapter IV

AI-Generated Summary

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Independent AI summary of health and genetic findings from the published study

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