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GWAS Study

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.

Ritchie MD, Denny JC, Zuvich RL et al.

23463857 PubMed ID
GWAS Study Type
45679 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

RM
Ritchie MD
DJ
Denny JC
ZR
Zuvich RL
CD
Crawford DC
SJ
Schildcrout JS
BL
Bastarache L
RA
Ramirez AH
MJ
Mosley JD
PJ
Pulley JM
BM
Basford MA
BY
Bradford Y
RL
Rasmussen LV
PJ
Pathak J
CC
Chute CG
KI
Kullo IJ
MC
McCarty CA
CR
Chisholm RL
KA
Kho AN
CC
Carlson CS
LE
Larson EB
JG
Jarvik GP
SN
Sotoodehnia N
MT
Manolio TA
LR
Li R
MD
Masys DR
HJ
Haines JL
RD
Roden DM
Chapter II

Abstract

Summary of the research findings

ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias.

5,272 European ancestry indiviudals

Chapter III

Study Statistics

Key metrics and study information

45679
Total Participants
GWAS
Study Type
Yes
Replicated
40,407 European ancestry individuals
Replication Participants
European
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

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